| Name | TOP2A |
| ID | P11388 |
| Role | substrate |
| Enzymatic Domains |
Toprim 455-572 PROSITE-ProRule
Topo IIA-type catalytic 715-1171 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | TOP2A | Ser1247 | KNENTEGsPQEDGVE | phosphorylation unknown | 7635160 | SIGNOR-30244 |
| CDK1 | TOP2A | Ser1361 | SPPKTKTsPKLSNKE | phosphorylation unknown | 7635160 | SIGNOR-30252 |
| PLK3 | TOP2A | Thr1343 | FSDFDEKtDDEDFVP | phosphorylation up-regulates | 18062778 | SIGNOR-159596 |
| PRKCB | TOP2A | Ser29 | EDAKKRLsVERIYQK | phosphorylation up-regulates activity | 12569090 | SIGNOR-249195 |
| PLK1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 19098900 | SIGNOR-182844 |
| CSNK2A1 | TOP2A | Ser1377 | KPQKSVVsDLEADDV | phosphorylation unknown | 7961967 | SIGNOR-250965 |
| CDK1 | TOP2A | Ser1354 | DFVPSDAsPPKTKTS | phosphorylation unknown | 7635160 | SIGNOR-30248 |
| CSNK2A1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 19098900 | SIGNOR-182840 |
| CSNK2A1 | TOP2A | Thr1343 | FSDFDEKtDDEDFVP | phosphorylation unknown | 9804834 | SIGNOR-250966 |
| PLK1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 18171681 | SIGNOR-160237 |
| PLK1 | TOP2A | Ser1337 | LDSDEDFsDFDEKTD | phosphorylation up-regulates | 18171681 | SIGNOR-160233 |
| CDK1 | TOP2A | Ser1393 | GSVPLSSsPPATHFP | phosphorylation unknown | 7635160 | SIGNOR-30256 |
| GSK3B | TOP2A | Ser1361 | SPPKTKTsPKLSNKE | phosphorylation down-regulates quantity by destabilization | 21254166 | SIGNOR-276301 |
| PRKCG | TOP2A | Ser29 | EDAKKRLsVERIYQK | phosphorylation up-regulates activity | 12569090 | SIGNOR-249196 |
| CSNK2A1 | TOP2A | Ser1365 | TKTSPKLsNKELKPQ | phosphorylation down-regulates quantity by destabilization | 21254166 | SIGNOR-276300 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | TOP2A PSer1247 | phosphorylation down-regulates ⊣ | TOP2A | 7635160 | SIGNOR-30244 |
| CDK1 | phosphorylation up-regulates → | TOP2A PSer1361 | phosphorylation down-regulates ⊣ | TOP2A | 7635160 | SIGNOR-30252 |
| PLK3 | phosphorylation up-regulates → | TOP2A PThr1343 | phosphorylation up-regulates → | TOP2A | 18062778 | SIGNOR-159596 |
| PRKCB | phosphorylation up-regulates → | TOP2A PSer29 | phosphorylation up-regulates → | TOP2A | 12569090 | SIGNOR-249195 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 19098900 | SIGNOR-182844 |
| CSNK2A1 | phosphorylation up-regulates → | TOP2A PSer1377 | phosphorylation down-regulates ⊣ | TOP2A | 7961967 | SIGNOR-250965 |
| CDK1 | phosphorylation up-regulates → | TOP2A PSer1354 | phosphorylation down-regulates ⊣ | TOP2A | 7635160 | SIGNOR-30248 |
| CSNK2A1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 19098900 | SIGNOR-182840 |
| CSNK2A1 | phosphorylation up-regulates → | TOP2A PThr1343 | phosphorylation down-regulates ⊣ | TOP2A | 9804834 | SIGNOR-250966 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 18171681 | SIGNOR-160237 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1337 | phosphorylation up-regulates → | TOP2A | 18171681 | SIGNOR-160233 |
| CDK1 | phosphorylation up-regulates → | TOP2A PSer1393 | phosphorylation down-regulates ⊣ | TOP2A | 7635160 | SIGNOR-30256 |
| GSK3B | phosphorylation up-regulates → | TOP2A PSer1361 | phosphorylation down-regulates ⊣ | TOP2A | 21254166 | SIGNOR-276301 |
| PRKCG | phosphorylation up-regulates → | TOP2A PSer29 | phosphorylation up-regulates → | TOP2A | 12569090 | SIGNOR-249196 |
| CSNK2A1 | phosphorylation up-regulates → | TOP2A PSer1365 | phosphorylation down-regulates ⊣ | TOP2A | 21254166 | SIGNOR-276300 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → unknown | TOP2A | SIGNOR-30244 |
| CDK1 | phosphorylation → unknown | TOP2A | SIGNOR-30252 |
| PLK3 | phosphorylation → up-regulates | TOP2A | SIGNOR-159596 |
| PRKCB | phosphorylation → up-regulates activity | TOP2A | SIGNOR-249195 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-182844 |
| CSNK2A1 | phosphorylation → unknown | TOP2A | SIGNOR-250965 |
| CDK1 | phosphorylation → unknown | TOP2A | SIGNOR-30248 |
| CSNK2A1 | phosphorylation → up-regulates | TOP2A | SIGNOR-182840 |
| CSNK2A1 | phosphorylation → unknown | TOP2A | SIGNOR-250966 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-160237 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-160233 |
| CDK1 | phosphorylation → unknown | TOP2A | SIGNOR-30256 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | TOP2A | SIGNOR-276301 |
| PRKCG | phosphorylation → up-regulates activity | TOP2A | SIGNOR-249196 |
| CSNK2A1 | phosphorylation down-regulates quantity by destabilization | TOP2A | SIGNOR-276300 |