Summary

Name TOP2A
Full Name DNA topoisomerase 2-alpha
Synonyms DNA topoisomerase II, alpha isozyme | TOP2
Primary ID P11388
Links - -
Type protein
Relations 30
Inhibitors valrubicin; etoposide; Doxorubicin hydrochloride; 2-(Decan-2-ylamino)ethyl 4-aminobenzoate; doxorubicin; idarubicin; Daunorubicin hydrochloride; teniposide; 4'-epidoxorubicin
Function Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).

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Relations


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Regulator Mechanism target score ℹ
+ CDK1