| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 19098900 | SIGNOR-182844 |
| CSNK2A1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 19098900 | SIGNOR-182840 |
| PLK1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 18171681 | SIGNOR-160237 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 19098900 | SIGNOR-182844 |
| CSNK2A1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 19098900 | SIGNOR-182840 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 18171681 | SIGNOR-160237 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-182844 |
| CSNK2A1 | phosphorylation → up-regulates | TOP2A | SIGNOR-182840 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-160237 |