| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | TOP2A | Thr1343 | FSDFDEKtDDEDFVP | phosphorylation unknown | 9804834 | SIGNOR-250966 |
| PLK3 | TOP2A | Thr1343 | FSDFDEKtDDEDFVP | phosphorylation up-regulates | 18062778 | SIGNOR-159596 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | TOP2A PThr1343 | phosphorylation down-regulates ⊣ | TOP2A | 9804834 | SIGNOR-250966 |
| PLK3 | phosphorylation up-regulates → | TOP2A PThr1343 | phosphorylation up-regulates → | TOP2A | 18062778 | SIGNOR-159596 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → unknown | TOP2A | SIGNOR-250966 |
| PLK3 | phosphorylation → up-regulates | TOP2A | SIGNOR-159596 |
