| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | TOP2A | Ser1361 | SPPKTKTsPKLSNKE | phosphorylation down-regulates quantity by destabilization | 21254166 | SIGNOR-276301 |
| CDK1 | TOP2A | Ser1361 | SPPKTKTsPKLSNKE | phosphorylation unknown | 7635160 | SIGNOR-30252 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | TOP2A PSer1361 | phosphorylation down-regulates ⊣ | TOP2A | 21254166 | SIGNOR-276301 |
| CDK1 | phosphorylation up-regulates → | TOP2A PSer1361 | phosphorylation down-regulates ⊣ | TOP2A | 7635160 | SIGNOR-30252 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | TOP2A | SIGNOR-276301 |
| CDK1 | phosphorylation → unknown | TOP2A | SIGNOR-30252 |
