| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | TOP2A | Ser1337 | LDSDEDFsDFDEKTD | phosphorylation up-regulates | 18171681 | SIGNOR-160233 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1337 | phosphorylation up-regulates → | TOP2A | 18171681 | SIGNOR-160233 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-160233 |
