| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCG | TOP2A | Ser29 | EDAKKRLsVERIYQK | phosphorylation up-regulates activity | 12569090 | SIGNOR-249196 |
| PRKCB | TOP2A | Ser29 | EDAKKRLsVERIYQK | phosphorylation up-regulates activity | 12569090 | SIGNOR-249195 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCG | phosphorylation up-regulates → | TOP2A PSer29 | phosphorylation up-regulates → | TOP2A | 12569090 | SIGNOR-249196 |
| PRKCB | phosphorylation up-regulates → | TOP2A PSer29 | phosphorylation up-regulates → | TOP2A | 12569090 | SIGNOR-249195 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCG | phosphorylation → up-regulates activity | TOP2A | SIGNOR-249196 |
| PRKCB | phosphorylation → up-regulates activity | TOP2A | SIGNOR-249195 |