| Name | BRAF |
| ID | P15056 |
| Role | kinase |
| Enzymatic Domains |
RBD 155-227 PROSITE-ProRule
Protein kinase 457-717 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | ABL1 | – | phosphorylation up-regulates activity | 28368422 | SIGNOR-278914 | |
| BRAF | BRAF | Ser614 | SHQFEQLsGSILWMA | phosphorylation down-regulates activity | 27345148 | SIGNOR-277255 |
| BRAF | BRAF | Ser465 | TVGQRIGsGSFGTVY | phosphorylation down-regulates activity | 31929109 | SIGNOR-277498 |
| BRAF | BRAF | Ser467 | GQRIGSGsFGTVYKG | phosphorylation down-regulates activity | 31929109 | SIGNOR-277499 |
| BRAF | PAX3 | Ser205 | APQSDEGsDIDSEPD | phosphorylation up-regulates activity | 27906130 | SIGNOR-278435 |
| BRAF | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 8668348 | SIGNOR-42664 |
| BRAF | MAP2K2 | Ser226 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8668348 | SIGNOR-42668 |
| BRAF | EEF1A1 | Ser21 | GHVDSGKsTTTGHLI | phosphorylation down-regulates quantity by destabilization | 22378069 | SIGNOR-276404 |
| BRAF | EEF1A1 | Thr88 | ETSKYYVtIIDAPGH | phosphorylation down-regulates quantity by destabilization | 22378069 | SIGNOR-276405 |
| BRAF | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates activity | 8131746 | SIGNOR-235475 |
| BRAF | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 8413257 | SIGNOR-39054 |
| BRAF | MAP2K1 | Ser248 | SVQSDIWsMGLSLVE | phosphorylation up-regulates activity | 8413257 | SIGNOR-39058 |
| BRAF | MAP2K1 | Ser252 | DIWSMGLsLVEMAVG | phosphorylation up-regulates activity | 8413257 | SIGNOR-39062 |
| BRAF | EEF1A2 | Ser21 | GHVDSGKsTTTGHLI | phosphorylation down-regulates quantity by destabilization | 22378069 | SIGNOR-276406 |
| BRAF | MAPK7 | Thr219 | AEHQYFMtEYVATRW | phosphorylation up-regulates quantity | 29483645 | SIGNOR-278352 |
| BRAF | MAPK7 | Tyr221 | HQYFMTEyVATRWYR | phosphorylation up-regulates quantity | 29483645 | SIGNOR-278353 |
| BRAF | NIBAN2 | – | phosphorylation down-regulates activity | 33684228 | SIGNOR-279595 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates | 8668348 | SIGNOR-244843 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates activity | 21900390 | SIGNOR-251988 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates activity | 8131746 | SIGNOR-244827 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates activity | 8413257 | SIGNOR-244831 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | phosphorylation up-regulates → | BRAF PSer614 | phosphorylation down-regulates ⊣ | BRAF | 27345148 | SIGNOR-277255 |
| BRAF | phosphorylation up-regulates → | BRAF PSer465 | phosphorylation down-regulates ⊣ | BRAF | 31929109 | SIGNOR-277498 |
| BRAF | phosphorylation up-regulates → | BRAF PSer467 | phosphorylation down-regulates ⊣ | BRAF | 31929109 | SIGNOR-277499 |
| BRAF | phosphorylation up-regulates → | PAX3 PSer205 | phosphorylation up-regulates → | PAX3 | 27906130 | SIGNOR-278435 |
| BRAF | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 8668348 | SIGNOR-42664 |
| BRAF | phosphorylation up-regulates → | MAP2K2 PSer226 | phosphorylation up-regulates → | MAP2K2 | 8668348 | SIGNOR-42668 |
| BRAF | phosphorylation up-regulates → | EEF1A1 PSer21 | phosphorylation down-regulates ⊣ | EEF1A1 | 22378069 | SIGNOR-276404 |
| BRAF | phosphorylation up-regulates → | EEF1A1 PThr88 | phosphorylation down-regulates ⊣ | EEF1A1 | 22378069 | SIGNOR-276405 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-235475 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39054 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer248 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39058 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer252 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39062 |
| BRAF | phosphorylation up-regulates → | EEF1A2 PSer21 | phosphorylation down-regulates ⊣ | EEF1A2 | 22378069 | SIGNOR-276406 |
| BRAF | phosphorylation up-regulates → | MAPK7 PThr219 | phosphorylation up-regulates → | MAPK7 | 29483645 | SIGNOR-278352 |
| BRAF | phosphorylation up-regulates → | MAPK7 PTyr221 | phosphorylation up-regulates → | MAPK7 | 29483645 | SIGNOR-278353 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BRAF | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278914 |
| BRAF | phosphorylation → down-regulates activity | BRAF | SIGNOR-277255 |
| BRAF | phosphorylation → down-regulates activity | BRAF | SIGNOR-277498 |
| BRAF | phosphorylation → down-regulates activity | BRAF | SIGNOR-277499 |
| BRAF | phosphorylation → up-regulates activity | PAX3 | SIGNOR-278435 |
| BRAF | phosphorylation → up-regulates | MAP2K2 | SIGNOR-42664 |
| BRAF | phosphorylation → up-regulates | MAP2K2 | SIGNOR-42668 |
| BRAF | phosphorylation down-regulates quantity by destabilization | EEF1A1 | SIGNOR-276404 |
| BRAF | phosphorylation down-regulates quantity by destabilization | EEF1A1 | SIGNOR-276405 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235475 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39054 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39058 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39062 |
| BRAF | phosphorylation down-regulates quantity by destabilization | EEF1A2 | SIGNOR-276406 |
| BRAF | phosphorylation → up-regulates quantity | MAPK7 | SIGNOR-278352 |
| BRAF | phosphorylation → up-regulates quantity | MAPK7 | SIGNOR-278353 |
| BRAF | phosphorylation → down-regulates activity | NIBAN2 | SIGNOR-279595 |
| BRAF | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244843 |
| BRAF | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-251988 |
| BRAF | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244827 |
| BRAF | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244831 |