Summary

Name BRAF
Full Name Serine/threonine-protein kinase B-raf
Synonyms Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 | BRAF1, RAFB1
Primary ID P15056
Links - -
Type protein
Relations 45
Pathways EGFR, Glioblastoma Multiforme, Malignant Melanoma, Acute Myeloid Leukemia, Inhibition of Apoptosis, IL6 , Colorectal Carcinoma, Luminal Breast Cancer, T cell activation, Rhabdomyosarcoma, Noonan syndrome, Thyroid cancer, KIT in AML, FLT3 in AML, BCR-ABL in AML, PI3K/AKT, ErbB receptors in cancer, RTKs in cancer
Inhibitors 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine; 5-[1-(2-hydroxyethyl)-3-pyridin-4-yl-4-pyrazolyl]-2,3-dihydroinden-1-one oxime; PLX-4720; CCT239065; sorafenib; regorafenib; sorafenib tosylate; dabrafenib; vemurafenib; GDC-0879
Function Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.69
Publications: 4 Organism: Mus Musculus, In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAP2K2 0.47
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.34
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, EGFR, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, PI3K/AKT, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, EGFR, ErbB receptors in cancer, Glioblastoma Multiforme, IL6 , Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.59
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.67
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MEK1/2 0.49
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, EGFR, ErbB receptors in cancer, Glioblastoma Multiforme, IL6 , Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, PI3K/AKT, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ down-regulates img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding BRAF 0.92
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, ErbB receptors in cancer, Noonan syndrome, PI3K/AKT, RTKs in cancer, T cell activation
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition BRAF 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2 0.49
Publications: 3 Organism: In Vitro, Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, EGFR, ErbB receptors in cancer, Glioblastoma Multiforme, IL6 , Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, PI3K/AKT, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation
+ up-regulates activity img/direct-activation.png binding BRAF 0.83
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer
+ down-regulates img/direct_inhibition.png chemical inhibition BRAF 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SLC5A5 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates activity img/direct-activation.png binding BRAF 0.41
Publications: 1 Organism: Mus Musculus
Pathways:Noonan syndrome
+ up-regulates quantity img/indirect-activation.png relocalization TGFB1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Thyroid cancer
+ up-regulates img/indirect-activation.png glycolysis 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BRAF 0.76
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 , Inhibition of Apoptosis, Malignant Melanoma, Noonan syndrome
+ up-regulates img/direct-activation.png binding BRAF 0.92
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:EGFR, ErbB receptors in cancer, Noonan syndrome, PI3K/AKT, RTKs in cancer, T cell activation