| Name | BRAF |
| ID | P15056 |
| Role | substrate |
| Enzymatic Domains |
RBD 155-227 PROSITE-ProRule
Protein kinase 457-717 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | BRAF | Ser151 | VARSNPKsPQKPIVR | phosphorylation down-regulates activity | 21478863 | SIGNOR-259920 |
| MAPK1 | BRAF | Thr753 | YACASPKtPIQAGGY | phosphorylation down-regulates activity | 16508002 | SIGNOR-236388 |
| PPP1CA | BRAF | – | dephosphorylation up-regulates activity | 29335436 | SIGNOR-277160 | |
| BRAF | BRAF | Ser467 | GQRIGSGsFGTVYKG | phosphorylation down-regulates activity | 31929109 | SIGNOR-277499 |
| AKT | BRAF | Ser364 | FGQRDRSsSAPNVHI | phosphorylation down-regulates | 10869359 | SIGNOR-244152 |
| BRAF | BRAF | Ser465 | TVGQRIGsGSFGTVY | phosphorylation down-regulates activity | 31929109 | SIGNOR-277498 |
| ERK1/2 | BRAF | Thr401 | STTGLSAtPPASLPG | phosphorylation down-regulates | 21135229 | SIGNOR-170339 |
| MAPK3 | BRAF | Ser151 | VARSNPKsPQKPIVR | phosphorylation down-regulates activity | 21478863 | SIGNOR-259921 |
| AKT3 | BRAF | Ser364 | FGQRDRSsSAPNVHI | phosphorylation down-regulates | 10869359 | SIGNOR-78693 |
| SGK1 | BRAF | – | phosphorylation down-regulates activity | 11410590 | SIGNOR-279110 | |
| PRKACA | BRAF | Ser429 | PQRERKSsSSSEDRN | phosphorylation down-regulates activity | 11510412 | SIGNOR-259922 |
| AKT2 | BRAF | Thr440 | EDRNRMKtLGRRDSS | phosphorylation down-regulates | 10869359 | SIGNOR-78689 |
| AKT1 | BRAF | Ser429 | PQRERKSsSSSEDRN | phosphorylation down-regulates activity | 10869359 | SIGNOR-251472 |
| AKT3 | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-78697 |
| Gbeta | BRAF | – | phosphorylation down-regulates | 16508002 | SIGNOR-270043 | |
| AKT | BRAF | Thr440 | EDRNRMKtLGRRDSS | phosphorylation down-regulates | 10869359 | SIGNOR-244156 |
| ERK1/2 | BRAF | Ser151 | VARSNPKsPQKPIVR | phosphorylation down-regulates activity | 21478863 | SIGNOR-259919 |
| AKT2 | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-78685 |
| MAPK3 | BRAF | Thr753 | YACASPKtPIQAGGY | phosphorylation down-regulates | 16508002 | SIGNOR-144827 |
| MAPK3 | BRAF | Thr753 | YACASPKtPIQAGGY | phosphorylation down-regulates | 19933846 | SIGNOR-161819 |
| PRKACA | BRAF | Ser429 | PQRERKSsSSSEDRN | phosphorylation down-regulates activity | 11510412 | SIGNOR-250339 |
| AKT | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-244160 |
| AKT1 | BRAF | Ser365 | GQRDRSSsAPNVHIN | phosphorylation down-regulates activity | 10869359 | SIGNOR-251471 |
| AKT2 | BRAF | Ser364 | FGQRDRSsSAPNVHI | phosphorylation down-regulates | 10869359 | SIGNOR-78681 |
| BRAF | BRAF | Ser614 | SHQFEQLsGSILWMA | phosphorylation down-regulates activity | 27345148 | SIGNOR-277255 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | BRAF PSer151 | phosphorylation down-regulates ⊣ | BRAF | 21478863 | SIGNOR-259920 |
| MAPK1 | phosphorylation up-regulates → | BRAF PThr753 | phosphorylation down-regulates ⊣ | BRAF | 16508002 | SIGNOR-236388 |
| BRAF | phosphorylation up-regulates → | BRAF PSer467 | phosphorylation down-regulates ⊣ | BRAF | 31929109 | SIGNOR-277499 |
| AKT | phosphorylation up-regulates → | BRAF PSer364 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244152 |
| BRAF | phosphorylation up-regulates → | BRAF PSer465 | phosphorylation down-regulates ⊣ | BRAF | 31929109 | SIGNOR-277498 |
| ERK1/2 | phosphorylation up-regulates → | BRAF PThr401 | phosphorylation down-regulates ⊣ | BRAF | 21135229 | SIGNOR-170339 |
| MAPK3 | phosphorylation up-regulates → | BRAF PSer151 | phosphorylation down-regulates ⊣ | BRAF | 21478863 | SIGNOR-259921 |
| AKT3 | phosphorylation up-regulates → | BRAF PSer364 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78693 |
| PRKACA | phosphorylation up-regulates → | BRAF PSer429 | phosphorylation down-regulates ⊣ | BRAF | 11510412 | SIGNOR-259922 |
| AKT2 | phosphorylation up-regulates → | BRAF PThr440 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78689 |
| AKT1 | phosphorylation up-regulates → | BRAF PSer429 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-251472 |
| AKT3 | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78697 |
| AKT | phosphorylation up-regulates → | BRAF PThr440 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244156 |
| ERK1/2 | phosphorylation up-regulates → | BRAF PSer151 | phosphorylation down-regulates ⊣ | BRAF | 21478863 | SIGNOR-259919 |
| AKT2 | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78685 |
| MAPK3 | phosphorylation up-regulates → | BRAF PThr753 | phosphorylation down-regulates ⊣ | BRAF | 16508002 | SIGNOR-144827 |
| MAPK3 | phosphorylation up-regulates → | BRAF PThr753 | phosphorylation down-regulates ⊣ | BRAF | 19933846 | SIGNOR-161819 |
| PRKACA | phosphorylation up-regulates → | BRAF PSer429 | phosphorylation down-regulates ⊣ | BRAF | 11510412 | SIGNOR-250339 |
| AKT | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244160 |
| AKT1 | phosphorylation up-regulates → | BRAF PSer365 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-251471 |
| AKT2 | phosphorylation up-regulates → | BRAF PSer364 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78681 |
| BRAF | phosphorylation up-regulates → | BRAF PSer614 | phosphorylation down-regulates ⊣ | BRAF | 27345148 | SIGNOR-277255 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-259920 |
| MAPK1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-236388 |
| PPP1CA | dephosphorylation → up-regulates activity | BRAF | SIGNOR-277160 |
| BRAF | phosphorylation → down-regulates activity | BRAF | SIGNOR-277499 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244152 |
| BRAF | phosphorylation → down-regulates activity | BRAF | SIGNOR-277498 |
| ERK1/2 | phosphorylation down-regulates | BRAF | SIGNOR-170339 |
| MAPK3 | phosphorylation → down-regulates activity | BRAF | SIGNOR-259921 |
| AKT3 | phosphorylation down-regulates | BRAF | SIGNOR-78693 |
| SGK1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-279110 |
| PRKACA | phosphorylation → down-regulates activity | BRAF | SIGNOR-259922 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78689 |
| AKT1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-251472 |
| AKT3 | phosphorylation down-regulates | BRAF | SIGNOR-78697 |
| Gbeta | phosphorylation down-regulates | BRAF | SIGNOR-270043 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244156 |
| ERK1/2 | phosphorylation → down-regulates activity | BRAF | SIGNOR-259919 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78685 |
| MAPK3 | phosphorylation down-regulates | BRAF | SIGNOR-144827 |
| MAPK3 | phosphorylation down-regulates | BRAF | SIGNOR-161819 |
| PRKACA | phosphorylation → down-regulates activity | BRAF | SIGNOR-250339 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244160 |
| AKT1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-251471 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78681 |
| BRAF | phosphorylation → down-regulates activity | BRAF | SIGNOR-277255 |