| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | BRAF | Ser429 | PQRERKSsSSSEDRN | phosphorylation down-regulates activity | 11510412 | SIGNOR-250339 |
| PRKACA | BRAF | Ser429 | PQRERKSsSSSEDRN | phosphorylation down-regulates activity | 11510412 | SIGNOR-259922 |
| AKT1 | BRAF | Ser429 | PQRERKSsSSSEDRN | phosphorylation down-regulates activity | 10869359 | SIGNOR-251472 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | BRAF PSer429 | phosphorylation down-regulates ⊣ | BRAF | 11510412 | SIGNOR-250339 |
| PRKACA | phosphorylation up-regulates → | BRAF PSer429 | phosphorylation down-regulates ⊣ | BRAF | 11510412 | SIGNOR-259922 |
| AKT1 | phosphorylation up-regulates → | BRAF PSer429 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-251472 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | BRAF | SIGNOR-250339 |
| PRKACA | phosphorylation → down-regulates activity | BRAF | SIGNOR-259922 |
| AKT1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-251472 |