| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT3 | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-78697 |
| AKT2 | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-78685 |
| AKT | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-244160 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT3 | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78697 |
| AKT2 | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78685 |
| AKT | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244160 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT3 | phosphorylation down-regulates | BRAF | SIGNOR-78697 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78685 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244160 |
