| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | BRAF | Thr753 | YACASPKtPIQAGGY | phosphorylation down-regulates | 16508002 | SIGNOR-144827 |
| MAPK3 | BRAF | Thr753 | YACASPKtPIQAGGY | phosphorylation down-regulates | 19933846 | SIGNOR-161819 |
| MAPK1 | BRAF | Thr753 | YACASPKtPIQAGGY | phosphorylation down-regulates activity | 16508002 | SIGNOR-236388 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | BRAF PThr753 | phosphorylation down-regulates ⊣ | BRAF | 16508002 | SIGNOR-144827 |
| MAPK3 | phosphorylation up-regulates → | BRAF PThr753 | phosphorylation down-regulates ⊣ | BRAF | 19933846 | SIGNOR-161819 |
| MAPK1 | phosphorylation up-regulates → | BRAF PThr753 | phosphorylation down-regulates ⊣ | BRAF | 16508002 | SIGNOR-236388 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | BRAF | SIGNOR-144827 |
| MAPK3 | phosphorylation down-regulates | BRAF | SIGNOR-161819 |
| MAPK1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-236388 |
