| Name | EZR |
| ID | P15311 |
| Role | substrate |
| Enzymatic Domains |
FERM 2-296 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation unknown | 15647376 | SIGNOR-133219 |
| LRRK2 | EZR | – | phosphorylation up-regulates activity | 17447891 | SIGNOR-279202 | |
| AKT2 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15531580 | SIGNOR-130260 |
| RHOA | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 35267019 | SIGNOR-268429 |
| SRC | EZR | Tyr478 | PPPPPPVyEPVSYHV | phosphorylation up-regulates | 15623525 | SIGNOR-132907 |
| AKT | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15531580 | SIGNOR-244263 |
| LCK | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation unknown | 12560083 | SIGNOR-251374 |
| CDK5 | EZR | Thr235 | YEKDDKLtPKIGFPW | phosphorylation up-regulates activity | 12769842 | SIGNOR-250665 |
| PRKCA | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15647376 | SIGNOR-133223 |
| SRC | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation up-regulates | 15647376 | SIGNOR-133227 |
| ROCK1 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 19386264 | SIGNOR-185567 |
| PRKCI | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 18270268 | SIGNOR-160855 |
| EGFR | EZR | Tyr354 | LMLRLQDyEEKTKKA | phosphorylation up-regulates | 15647376 | SIGNOR-133215 |
| SRC | EZR | Tyr478 | PPPPPPVyEPVSYHV | phosphorylation up-regulates | 22397367 | SIGNOR-196443 |
| GRK2 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15843435 | SIGNOR-135622 |
| PTP4A3 | EZR | Thr567 | QGRDKYKtLRQIRQG | dephosphorylation down-regulates activity | 18078820 | SIGNOR-248342 |
| STK26 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 19386264 | SIGNOR-185563 |
| SYK | EZR | – | phosphorylation up-regulates activity | 23703860 | SIGNOR-279129 | |
| STK10 | EZR | Tyr565 | MRQGRDKyKTLRQIR | phosphorylation up-regulates activity | 28430576 | SIGNOR-278204 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation down-regulates ⊣ | EZR | 15647376 | SIGNOR-133219 |
| AKT2 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15531580 | SIGNOR-130260 |
| RHOA | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 35267019 | SIGNOR-268429 |
| SRC | phosphorylation up-regulates → | EZR PTyr478 | phosphorylation up-regulates → | EZR | 15623525 | SIGNOR-132907 |
| AKT | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15531580 | SIGNOR-244263 |
| LCK | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation down-regulates ⊣ | EZR | 12560083 | SIGNOR-251374 |
| CDK5 | phosphorylation up-regulates → | EZR PThr235 | phosphorylation up-regulates → | EZR | 12769842 | SIGNOR-250665 |
| PRKCA | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15647376 | SIGNOR-133223 |
| SRC | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation up-regulates → | EZR | 15647376 | SIGNOR-133227 |
| ROCK1 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 19386264 | SIGNOR-185567 |
| PRKCI | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 18270268 | SIGNOR-160855 |
| EGFR | phosphorylation up-regulates → | EZR PTyr354 | phosphorylation up-regulates → | EZR | 15647376 | SIGNOR-133215 |
| SRC | phosphorylation up-regulates → | EZR PTyr478 | phosphorylation up-regulates → | EZR | 22397367 | SIGNOR-196443 |
| GRK2 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15843435 | SIGNOR-135622 |
| PTP4A3 | dephosphorylation down-regulates ⊣ | EZR PThr567 | dephosphorylation up-regulates → | EZR | 18078820 | SIGNOR-248342 |
| STK26 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 19386264 | SIGNOR-185563 |
| STK10 | phosphorylation up-regulates → | EZR PTyr565 | phosphorylation up-regulates → | EZR | 28430576 | SIGNOR-278204 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → unknown | EZR | SIGNOR-133219 |
| LRRK2 | phosphorylation → up-regulates activity | EZR | SIGNOR-279202 |
| AKT2 | phosphorylation → up-regulates | EZR | SIGNOR-130260 |
| RHOA | phosphorylation → up-regulates activity | EZR | SIGNOR-268429 |
| SRC | phosphorylation → up-regulates | EZR | SIGNOR-132907 |
| AKT | phosphorylation → up-regulates | EZR | SIGNOR-244263 |
| LCK | phosphorylation → unknown | EZR | SIGNOR-251374 |
| CDK5 | phosphorylation → up-regulates activity | EZR | SIGNOR-250665 |
| PRKCA | phosphorylation → up-regulates | EZR | SIGNOR-133223 |
| SRC | phosphorylation → up-regulates | EZR | SIGNOR-133227 |
| ROCK1 | phosphorylation → up-regulates | EZR | SIGNOR-185567 |
| PRKCI | phosphorylation → up-regulates | EZR | SIGNOR-160855 |
| EGFR | phosphorylation → up-regulates | EZR | SIGNOR-133215 |
| SRC | phosphorylation → up-regulates | EZR | SIGNOR-196443 |
| GRK2 | phosphorylation → up-regulates | EZR | SIGNOR-135622 |
| PTP4A3 | dephosphorylation → down-regulates activity | EZR | SIGNOR-248342 |
| STK26 | phosphorylation → up-regulates | EZR | SIGNOR-185563 |
| SYK | phosphorylation → up-regulates activity | EZR | SIGNOR-279129 |
| STK10 | phosphorylation → up-regulates activity | EZR | SIGNOR-278204 |