| + |
CDK5 | up-regulates activity 
phosphorylation
|
EZR |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250665 |
Thr235 |
YEKDDKLtPKIGFPW |
Homo sapiens |
SAOS-2 Cell |
| pmid |
sentence |
| 12769842 |
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTP4A3 | down-regulates activity 
dephosphorylation
|
EZR |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248342 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18078820 |
Here we report the identification of Ezrin as a specific and direct cellular substrate of PRL-3. In HCT116 colon cancer cell line, Ezrin was identified among the cellular proteins whose phosphorylation level decreased upon ectopic over-expression of wtPRL-3 but not of catalytically inactive PRL-3 mutants. Although PRL-3 over-expression in HCT116 cells appeared to affect Ezrin phosphorylation status at both tyrosine residues and Thr567, suppression of the endogenous protein by RNA interference pointed to Ezrin-Thr567 as the residue primarily affected by PRL-3 action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCA | up-regulates
phosphorylation
|
EZR |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133223 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
A-431 Cell |
| pmid |
sentence |
| 15647376 |
Phosphorylation of ezrin is required for both conformational activation and for signaling to downstream events. The activating c-terminal threonine phosphorylation on t567 was first described to be downstream of the rho pathway (matsui et al., 1998). Additional studies have implicated protein kinase c (pkc) in the phosphorylation of ezrin t567. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RHOA | up-regulates activity
phosphorylation
|
EZR |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268429 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates
phosphorylation
|
EZR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244263 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
| pmid |
sentence |
| 15531580 |
Purified akt directly phosphorylates recombinant ezrin at threonine 567 in vitro in an atp-dependent manner. ezrin activation after initiation of na+-glucose cotransport requires akt2 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROCK1 | up-regulates
phosphorylation
|
EZR |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185567 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
| pmid |
sentence |
| 19386264 |
Activation of ezrin is mediated by initial pip2 binding and subsequent phosphorylation of threonine 567. We performed an in vitro kinase assay with 80 selected kinases on an ezrin peptide containing the t567 phosphorylation site (figure 3a). In this screen, we identified the mst and rock kinases as the most potent kinases for the ezrin peptide |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK26 | up-regulates
phosphorylation
|
EZR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185563 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
| pmid |
sentence |
| 19386264 |
Activation of ezrin is mediated by initial pip2 binding and subsequent phosphorylation of threonine 567. Mst4 phosphorylates the regulatory t567 residue of ezrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | up-regulates
phosphorylation
|
EZR |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130260 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
| pmid |
sentence |
| 15531580 |
Purified akt directly phosphorylates recombinant ezrin at threonine 567 in vitro in an atp-dependent manner. ezrin activation after initiation of na+-glucose cotransport requires akt2 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK2 | up-regulates
phosphorylation
|
EZR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135622 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
| pmid |
sentence |
| 15843435 |
Grk2 phosphorylates glutathione s-transferase (gst)-ezrin, but not an ezrin fusion protein lacking threonine 567 (t567), in vitro. These results suggest that t567, the regulatory phosphorylation site responsible for maintaining ezrin in its active conformation, represents the principle site of grk2-mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCI | up-regulates
phosphorylation
|
EZR |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160855 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 18270268 |
Pkciota phosphorylated ezrin on t567 in vitro, and in sf9 cells that do not activate human ezrin. we conclude that, although other molecular mechanisms contribute to ezrin activation, apically localized phosphorylation by pkciota is essential for the activation and normal distribution of ezrin at the early stages of intestinal epithelial cell differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR |
phosphorylation
|
EZR |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133219 |
Tyr146 |
KEVHKSGyLSSERLI |
Homo sapiens |
A-431 Cell |
| pmid |
sentence |
| 15647376 |
Here we report the identification of the tyrosine phosphorylation sites in ezrin using bacterially expressed protein as a substrate for in vitro phosphorylation with the egf receptor. tyrosines 145 and 353 were identified as the sites of phosphorylation. but as of yet the role of ezrin phosphorylation at y145 is unknown. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates
phosphorylation
|
EZR |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133227 |
Tyr146 |
KEVHKSGyLSSERLI |
Homo sapiens |
|
| pmid |
sentence |
| 15647376 |
N this study we have demonstrated that ezrin y145 is a direct target for phosphorylation by the tyrosine kinase src evidence from this study suggests that a positive feedback loop exists whereby src-mediated ezrin y145 phosphorylation sustains src activity._ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196443 |
Tyr478 |
PPPPPPVyEPVSYHV |
Homo sapiens |
|
| pmid |
sentence |
| 22397367 |
Ezrin, a member of the erm family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. In particular, ezrin phosphorylation on y477 by src is specific to ezrin within the erm family, and is required for hgf-induced scattering of epithelial cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132907 |
Tyr478 |
PPPPPPVyEPVSYHV |
Homo sapiens |
|
| pmid |
sentence |
| 15623525 |
Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
LCK |
phosphorylation
|
EZR |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251374 |
Tyr146 |
KEVHKSGyLSSERLI |
in vitro |
|
| pmid |
sentence |
| 12560083 |
Lck phosphorylated ezrin in vitro, and the major phosphotyrosine was identified as Y145. Whether tyrosine phosphorylation of ezrin is an alternative mechanism to regulate dynamic changes of the actin cytoskeleton, as has been suggested in EGF-, PDGF- or HGF-treated epithelial cells, is still unclear. Alternatively, Lck-induced tyrosine phosphorylation of ezrin may be linked to its other functions, including participation in signaling pathways that control proliferation and apoptosis |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
EGFR | up-regulates
phosphorylation
|
EZR |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133215 |
Tyr354 |
LMLRLQDyEEKTKKA |
Homo sapiens |
A-431 Cell |
| pmid |
sentence |
| 15647376 |
Ezrin was initially identified as a substrate for tyrosine phosphorylation by egfr (bretscher, 1989) and phosphorylation of residues y145 and y353 were detected to high stoichiometry after egf treatment . Phosphorylation of ezrin at y353 has been delineated to signal survival during epithelial cell differentiation via the phosphatidylinositol 3-kinase (pi3k)/akt pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK10 | up-regulates activity
phosphorylation
|
EZR |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278204 |
Tyr565 |
MRQGRDKyKTLRQIR |
Homo sapiens |
|
| pmid |
sentence |
| 28430576 |
Ezrin activation by LOK phosphorylation involves a PIP 2 -dependent wedge mechanism.|The specificity of kinases depends on local peptide consensus sequences, which in the case of ezrin phosphorylation by LOK involves the hydrophobic residue Y565 positioned -2 residues from T567. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VPS11 | up-regulates activity
binding
|
EZR |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261311 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21148287 |
The interaction between the full-length Vps11 and ezrin was confirmed by immunoprecipitation and GST-pull down. ERM proteins and the HOPS complex are required for the transition from early to late endosomes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIX1 | up-regulates quantity
transcriptional regulation
|
EZR |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16488997 |
We now show that the gene encoding Ezrin is a direct transcriptional target of Six1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZR | up-regulates
relocalization
|
FES |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18046454 |
The recruitment and the activation of fes to the cell-cell contacts in confluent cells depend on its interaction with ezrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRRK2 | up-regulates activity
phosphorylation
|
EZR |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17447891 |
LRRK2 also phosphorylated ezrin and radixin, which are related to moesin, at the residue equivalent to Thr558, as well as a peptide (LRRKtide: RLGRDKYKTLRQIRQ) encompassing Thr558. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SYK | up-regulates activity
phosphorylation
|
EZR |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23703860 |
Phospho-SYK has also been shown to specifically activate ezrin upon CD81 engagement.|We found that the activated SYK led to a time dependent phosphorylation of ezrin (pY354 and pThr567) and radixin (pThr564) (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZR | up-regulates 
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268432 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. Taken together, these results suggest that Rev-erbα potentiates platelet activation via an OPHN-1-mediated RhoA/ERM signalling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZR | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259375 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell |
| pmid |
sentence |
| 16488997 |
Ezrin is indispensable for Six1-induced metastasis and highly expressed in a panel of representative pediatric cancers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
EZR
- 
- 