| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation unknown | 15647376 | SIGNOR-133219 |
| LCK | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation unknown | 12560083 | SIGNOR-251374 |
| SRC | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation up-regulates | 15647376 | SIGNOR-133227 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation down-regulates ⊣ | EZR | 15647376 | SIGNOR-133219 |
| LCK | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation down-regulates ⊣ | EZR | 12560083 | SIGNOR-251374 |
| SRC | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation up-regulates → | EZR | 15647376 | SIGNOR-133227 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → unknown | EZR | SIGNOR-133219 |
| LCK | phosphorylation → unknown | EZR | SIGNOR-251374 |
| SRC | phosphorylation → up-regulates | EZR | SIGNOR-133227 |
