| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15647376 | SIGNOR-133223 |
| ROCK1 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 19386264 | SIGNOR-185567 |
| PRKCI | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 18270268 | SIGNOR-160855 |
| GRK2 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15843435 | SIGNOR-135622 |
| PTP4A3 | EZR | Thr567 | QGRDKYKtLRQIRQG | dephosphorylation down-regulates activity | 18078820 | SIGNOR-248342 |
| STK26 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 19386264 | SIGNOR-185563 |
| AKT2 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15531580 | SIGNOR-130260 |
| RHOA | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 35267019 | SIGNOR-268429 |
| AKT | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15531580 | SIGNOR-244263 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15647376 | SIGNOR-133223 |
| ROCK1 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 19386264 | SIGNOR-185567 |
| PRKCI | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 18270268 | SIGNOR-160855 |
| GRK2 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15843435 | SIGNOR-135622 |
| PTP4A3 | dephosphorylation down-regulates ⊣ | EZR PThr567 | dephosphorylation up-regulates → | EZR | 18078820 | SIGNOR-248342 |
| STK26 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 19386264 | SIGNOR-185563 |
| AKT2 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15531580 | SIGNOR-130260 |
| RHOA | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 35267019 | SIGNOR-268429 |
| AKT | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15531580 | SIGNOR-244263 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates | EZR | SIGNOR-133223 |
| ROCK1 | phosphorylation → up-regulates | EZR | SIGNOR-185567 |
| PRKCI | phosphorylation → up-regulates | EZR | SIGNOR-160855 |
| GRK2 | phosphorylation → up-regulates | EZR | SIGNOR-135622 |
| PTP4A3 | dephosphorylation → down-regulates activity | EZR | SIGNOR-248342 |
| STK26 | phosphorylation → up-regulates | EZR | SIGNOR-185563 |
| AKT2 | phosphorylation → up-regulates | EZR | SIGNOR-130260 |
| RHOA | phosphorylation → up-regulates activity | EZR | SIGNOR-268429 |
| AKT | phosphorylation → up-regulates | EZR | SIGNOR-244263 |
