| Name | ATF2 |
| ID | P15336 |
| Role | substrate |
| Enzymatic Domains |
bZIP 352-415 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| p38 | ATF2 | – | phosphorylation up-regulates | 10085140 | SIGNOR-270124 | |
| MAPK9 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 7737130 | SIGNOR-32433 |
| MAPK8 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 7737130 | SIGNOR-32421 |
| JNK | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 15916964 | SIGNOR-137627 |
| MAPK9 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 7737130 | SIGNOR-32429 |
| MAPK3 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 12110590 | SIGNOR-90533 |
| VRK1 | ATF2 | Thr73 | ADQTPTPtRFLKNCE | phosphorylation up-regulates | 15105425 | SIGNOR-124334 |
| VRK1 | ATF2 | Ser62 | FGPARNDsVIVADQT | phosphorylation up-regulates | 15105425 | SIGNOR-124330 |
| ATM | ATF2 | Ser490 | QSTEPALsQIVMAPS | phosphorylation up-regulates | 15916964 | SIGNOR-137619 |
| MAPK11 | ATF2 | – | phosphorylation up-regulates | 10085140 | SIGNOR-65586 | |
| MAPK3 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-163254 |
| MAPK1 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-163242 |
| MAPK8 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 7824938 | SIGNOR-33918 |
| MAPK9 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-163262 |
| PLK3 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 21098032 | SIGNOR-170008 |
| ERK1/2 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-260755 |
| MAPK14 | ATF2 | – | phosphorylation up-regulates activity | 10085140 | SIGNOR-65593 | |
| AKT2 | ATF2 | – | phosphorylation up-regulates activity | 25890336 | SIGNOR-280178 | |
| PLK3 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 21098032 | SIGNOR-170004 |
| MAPK1 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 12110590 | SIGNOR-90517 |
| ROBO | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 15916964 | SIGNOR-137639 |
| ATM | ATF2 | Ser498 | QIVMAPSsQSQPSGS | phosphorylation up-regulates | 15916964 | SIGNOR-137623 |
| MAPK14 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 12110590 | SIGNOR-90525 |
| MAPK3 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 20068231 | SIGNOR-163258 |
| MAPK14 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 10085140 | SIGNOR-65601 |
| MAPK8 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 7737130 | SIGNOR-32425 |
| JNK | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 15916964 | SIGNOR-137631 |
| PAK1 | ATF2 | Ser62 | FGPARNDsVIVADQT | phosphorylation down-regulates activity | 28918037 | SIGNOR-279377 |
| MAPK14 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 12110590 | SIGNOR-90521 |
| MAPK3 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 12110590 | SIGNOR-90529 |
| PLK3 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 20068231 | SIGNOR-163274 |
| MAPK14 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 10085140 | SIGNOR-65597 |
| PLK3 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-163270 |
| MAPK9 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 20068231 | SIGNOR-163266 |
| Gbeta | ATF2 | – | phosphorylation up-regulates | 12110590 | SIGNOR-270073 | |
| ROBO | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 15916964 | SIGNOR-137635 |
| MAPK14 | ATF2 | Ser90 | GLFNELAsPFENEFK | phosphorylation up-regulates activity | 10085140 | SIGNOR-250090 |
| PRKCE | ATF2 | Thr52 | HKHKHEMtLKFGPAR | phosphorylation up-regulates | 22304920 | SIGNOR-195761 |
| MAPK8 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 7824938 | SIGNOR-33914 |
| MAPK12 | ATF2 | – | phosphorylation up-regulates | 10085140 | SIGNOR-65589 | |
| MAPK14 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 20068231 | SIGNOR-163250 |
| MAPK14 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-163246 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 7737130 | SIGNOR-32433 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 7737130 | SIGNOR-32421 |
| JNK | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137627 |
| MAPK9 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 7737130 | SIGNOR-32429 |
| MAPK3 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 12110590 | SIGNOR-90533 |
| VRK1 | phosphorylation up-regulates → | ATF2 PThr73 | phosphorylation up-regulates → | ATF2 | 15105425 | SIGNOR-124334 |
| VRK1 | phosphorylation up-regulates → | ATF2 PSer62 | phosphorylation up-regulates → | ATF2 | 15105425 | SIGNOR-124330 |
| ATM | phosphorylation up-regulates → | ATF2 PSer490 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137619 |
| MAPK3 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163254 |
| MAPK1 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163242 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 7824938 | SIGNOR-33918 |
| MAPK9 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163262 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 21098032 | SIGNOR-170008 |
| ERK1/2 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-260755 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 21098032 | SIGNOR-170004 |
| MAPK1 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 12110590 | SIGNOR-90517 |
| ROBO | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137639 |
| ATM | phosphorylation up-regulates → | ATF2 PSer498 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137623 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 12110590 | SIGNOR-90525 |
| MAPK3 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163258 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 10085140 | SIGNOR-65601 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 7737130 | SIGNOR-32425 |
| JNK | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137631 |
| PAK1 | phosphorylation up-regulates → | ATF2 PSer62 | phosphorylation down-regulates ⊣ | ATF2 | 28918037 | SIGNOR-279377 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 12110590 | SIGNOR-90521 |
| MAPK3 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 12110590 | SIGNOR-90529 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163274 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 10085140 | SIGNOR-65597 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163270 |
| MAPK9 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163266 |
| ROBO | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137635 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PSer90 | phosphorylation up-regulates → | ATF2 | 10085140 | SIGNOR-250090 |
| PRKCE | phosphorylation up-regulates → | ATF2 PThr52 | phosphorylation up-regulates → | ATF2 | 22304920 | SIGNOR-195761 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 7824938 | SIGNOR-33914 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163250 |
| MAPK14 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163246 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| p38 | phosphorylation → up-regulates | ATF2 | SIGNOR-270124 |
| MAPK9 | phosphorylation → up-regulates | ATF2 | SIGNOR-32433 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-32421 |
| JNK | phosphorylation → up-regulates | ATF2 | SIGNOR-137627 |
| MAPK9 | phosphorylation → up-regulates | ATF2 | SIGNOR-32429 |
| MAPK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-90533 |
| VRK1 | phosphorylation → up-regulates | ATF2 | SIGNOR-124334 |
| VRK1 | phosphorylation → up-regulates | ATF2 | SIGNOR-124330 |
| ATM | phosphorylation → up-regulates | ATF2 | SIGNOR-137619 |
| MAPK11 | phosphorylation → up-regulates | ATF2 | SIGNOR-65586 |
| MAPK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-163254 |
| MAPK1 | phosphorylation → up-regulates | ATF2 | SIGNOR-163242 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-33918 |
| MAPK9 | phosphorylation → up-regulates | ATF2 | SIGNOR-163262 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-170008 |
| ERK1/2 | phosphorylation → up-regulates | ATF2 | SIGNOR-260755 |
| MAPK14 | phosphorylation → up-regulates activity | ATF2 | SIGNOR-65593 |
| AKT2 | phosphorylation → up-regulates activity | ATF2 | SIGNOR-280178 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-170004 |
| MAPK1 | phosphorylation → up-regulates | ATF2 | SIGNOR-90517 |
| ROBO | phosphorylation → up-regulates | ATF2 | SIGNOR-137639 |
| ATM | phosphorylation → up-regulates | ATF2 | SIGNOR-137623 |
| MAPK14 | phosphorylation → up-regulates | ATF2 | SIGNOR-90525 |
| MAPK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-163258 |
| MAPK14 | phosphorylation → up-regulates | ATF2 | SIGNOR-65601 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-32425 |
| JNK | phosphorylation → up-regulates | ATF2 | SIGNOR-137631 |
| PAK1 | phosphorylation → down-regulates activity | ATF2 | SIGNOR-279377 |
| MAPK14 | phosphorylation → up-regulates | ATF2 | SIGNOR-90521 |
| MAPK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-90529 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-163274 |
| MAPK14 | phosphorylation → up-regulates | ATF2 | SIGNOR-65597 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-163270 |
| MAPK9 | phosphorylation → up-regulates | ATF2 | SIGNOR-163266 |
| Gbeta | phosphorylation → up-regulates | ATF2 | SIGNOR-270073 |
| ROBO | phosphorylation → up-regulates | ATF2 | SIGNOR-137635 |
| MAPK14 | phosphorylation → up-regulates activity | ATF2 | SIGNOR-250090 |
| PRKCE | phosphorylation → up-regulates | ATF2 | SIGNOR-195761 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-33914 |
| MAPK12 | phosphorylation → up-regulates | ATF2 | SIGNOR-65589 |
| MAPK14 | phosphorylation → up-regulates | ATF2 | SIGNOR-163250 |
| MAPK14 | phosphorylation → up-regulates | ATF2 | SIGNOR-163246 |