Summary

Name ATF2
Full Name Cyclic AMP-dependent transcription factor ATF-2
Synonyms cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, HB16, Histone acetyltransferase ATF2, cAMP response element-binding protein CRE-BP1 | CREB2, CREBP1
Primary ID P15336
Links - -
Type protein
Relations 46
Pathways SAPK/JNK Signaling
Function Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATF2 0.49
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.37
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.37
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.46
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.49
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.42
Publications: 4 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ATF2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FGF21 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLAT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF2 0.28
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation POLB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ST3GAL5 0.14
Publications: 1 Organism: Homo Sapiens