Entity Details

Name TCF3
ID P15923
Role substrate
Enzymatic Domains
bHLH 549-602
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAP3K10TCF3Ser352SSNNFSSsPSTPVGSphosphorylation
down-regulates
19801649SIGNOR-161527
MAPK3TCF3Thr355NFSSSPStPVGSPQGphosphorylation
down-regulates quantity by destabilization
14592976SIGNOR-249117
MAP3K10TCF3Ser341KALASIYsPDHSSNNphosphorylation
down-regulates
19801649SIGNOR-161523
MAP3K10TCF3Thr355NFSSSPStPVGSPQGphosphorylation
down-regulates
19801649SIGNOR-161544
MAPK14TCF3Ser139 LNSPGPLsPSGMKGTphosphorylation
up-regulates activity
15719023SIGNOR-134194
PAK5TCF3Ser39NGKGRPAsLAGAQFGphosphorylation
up-regulates activity
26212009SIGNOR-275653
ERK1/2TCF3–phosphorylation
down-regulates quantity by destabilization
14592976SIGNOR-270139
HIPK2TCF3–phosphorylation
down-regulates activity
21285352SIGNOR-279193
MAPKAPK2TCF3–phosphorylation
up-regulates
20626350SIGNOR-166643
CSNK1ETCF3–phosphorylation
up-regulates
11524435SIGNOR-110056
MAP3K10TCF3Ser359SPSTPVGsPQGLAGTphosphorylation
down-regulates
19801649SIGNOR-161531
GbetaTCF3–phosphorylation
down-regulates quantity by destabilization
14592976SIGNOR-270009
MAPK1TCF3Thr355NFSSSPStPVGSPQGphosphorylation
down-regulates quantity by destabilization
14592976SIGNOR-249451
MAP3K10TCF3Ser379 AGAPGALsPSYDGGLphosphorylation
down-regulates
19801649SIGNOR-161540
MAPK11TCF3Ser139 LNSPGPLsPSGMKGTphosphorylation
up-regulates
15719023SIGNOR-134190
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAP3K10phosphorylation
up-regulates
→
TCF3
PSer352
phosphorylation
down-regulates
⊣
TCF319801649SIGNOR-161527
MAPK3phosphorylation
up-regulates
→
TCF3
PThr355
phosphorylation
down-regulates
⊣
TCF314592976SIGNOR-249117
MAP3K10phosphorylation
up-regulates
→
TCF3
PSer341
phosphorylation
down-regulates
⊣
TCF319801649SIGNOR-161523
MAP3K10phosphorylation
up-regulates
→
TCF3
PThr355
phosphorylation
down-regulates
⊣
TCF319801649SIGNOR-161544
MAPK14phosphorylation
up-regulates
→
TCF3
PSer139
phosphorylation
up-regulates
→
TCF315719023SIGNOR-134194
PAK5phosphorylation
up-regulates
→
TCF3
PSer39
phosphorylation
up-regulates
→
TCF326212009SIGNOR-275653
MAP3K10phosphorylation
up-regulates
→
TCF3
PSer359
phosphorylation
down-regulates
⊣
TCF319801649SIGNOR-161531
MAPK1phosphorylation
up-regulates
→
TCF3
PThr355
phosphorylation
down-regulates
⊣
TCF314592976SIGNOR-249451
MAP3K10phosphorylation
up-regulates
→
TCF3
PSer379
phosphorylation
down-regulates
⊣
TCF319801649SIGNOR-161540
MAPK11phosphorylation
up-regulates
→
TCF3
PSer139
phosphorylation
up-regulates
→
TCF315719023SIGNOR-134190
Regulator Mechanism/Effect Target SIGNOR-ID
MAP3K10phosphorylation
img/direct_inhibition.png
down-regulates
TCF3SIGNOR-161527
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TCF3SIGNOR-249117
MAP3K10phosphorylation
img/direct_inhibition.png
down-regulates
TCF3SIGNOR-161523
MAP3K10phosphorylation
img/direct_inhibition.png
down-regulates
TCF3SIGNOR-161544
MAPK14phosphorylation
→
up-regulates activity
TCF3SIGNOR-134194
PAK5phosphorylation
→
up-regulates activity
TCF3SIGNOR-275653
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TCF3SIGNOR-270139
HIPK2phosphorylation
→
down-regulates activity
TCF3SIGNOR-279193
MAPKAPK2phosphorylation
→
up-regulates
TCF3SIGNOR-166643
CSNK1Ephosphorylation
→
up-regulates
TCF3SIGNOR-110056
MAP3K10phosphorylation
img/direct_inhibition.png
down-regulates
TCF3SIGNOR-161531
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TCF3SIGNOR-270009
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TCF3SIGNOR-249451
MAP3K10phosphorylation
img/direct_inhibition.png
down-regulates
TCF3SIGNOR-161540
MAPK11phosphorylation
→
up-regulates
TCF3SIGNOR-134190