| + |
MAPK14 | up-regulates activity 
phosphorylation
|
TCF3 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134194 |
Ser139 |
LNSPGPLsPSGMKGT |
Homo sapiens |
|
| pmid |
sentence |
| 15719023 |
Here we show that p38 mapk, whose activity is essential for myogenesis, regulates myod/e47 heterodimerization. Phosphorylation of e47 at ser140 by p38 induces myod/e47 association and activation of muscle-specific transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK11 | up-regulates
phosphorylation
|
TCF3 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134190 |
Ser139 |
LNSPGPLsPSGMKGT |
Homo sapiens |
|
| pmid |
sentence |
| 15719023 |
Here we show that p38 mapk, whose activity is essential for myogenesis, regulates myod/e47 heterodimerization. Phosphorylation of e47 at ser140 by p38 induces myod/e47 association and activation of muscle-specific transcription, while the nonphosphorylatable e47 mutant ser140ala fails to heterodimerize with myod and displays impaired myogenic potentia |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
MAP3K10 | down-regulates 
phosphorylation
|
TCF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161523 |
Ser341 |
KALASIYsPDHSSNN |
Homo sapiens |
|
| pmid |
sentence |
| 19801649 |
Mlk2 inhibits e47 transactivation activity on the trkb promote |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161527 |
Ser352 |
SSNNFSSsPSTPVGS |
Homo sapiens |
|
| pmid |
sentence |
| 19801649 |
Mlk2 inhibits e47 transactivation activity on the trkb promote |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161531 |
Ser359 |
SPSTPVGsPQGLAGT |
Homo sapiens |
|
| pmid |
sentence |
| 19801649 |
Mlk2 inhibits e47 transactivation activity on the trkb promote |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161540 |
Ser379 |
AGAPGALsPSYDGGL |
Homo sapiens |
|
| pmid |
sentence |
| 19801649 |
Mlk2 inhibits e47 transactivation activity on the trkb promote |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161544 |
Thr355 |
NFSSSPStPVGSPQG |
Homo sapiens |
|
| pmid |
sentence |
| 19801649 |
Mlk2 inhibits e47 transactivation activity on the trkb promote |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
PAK5 | up-regulates activity
phosphorylation
|
TCF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275653 |
Ser39 |
NGKGRPAsLAGAQFG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 26212009 |
The p21-activated kinase 5 (PAK5) is overexpressed in advanced cancer and the transcription factor E47 is a direct repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT). |In this study, we found that PAK5-mediated E47 phosphorylation promoted EMT in advanced colon cancer. PAK5 interacted with E47 and phosphorylated E47 on Ser39 under hepatocyte growth factor (HGF) stimulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
TCF3 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249451 |
Thr355 |
NFSSSPStPVGSPQG |
Mus musculus |
|
| pmid |
sentence |
| 14592976 |
Notch-induced degradation requires phosphorylation of E47 by p42/p44 MAP kinases. |Wild_type E47 but not the Mm mutant reacted to the antibodies, suggesting that E47 is at least phosphorylated at the M2 site (Figure 3A)|anti_phospho_M2 peptide (SSPSpTPVGSPQG) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
TCF3 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249117 |
Thr355 |
NFSSSPStPVGSPQG |
Mus musculus |
|
| pmid |
sentence |
| 14592976 |
Notch-induced degradation requires phosphorylation of E47 by p42/p44 MAP kinases. |Wild_type E47 but not the Mm mutant reacted to the antibodies, suggesting that E47 is at least phosphorylated at the M2 site (Figure 3A)|anti_phospho_M2 peptide (SSPSpTPVGSPQG) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NOTCH2 | down-regulates
binding
|
TCF3 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9528794 |
In an effort to identify processes that regulate e47, and potentially b-cell development, we found that activated notch1 and notch2 effectively inhibit e47 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF3 | down-regulates quantity by repression
transcriptional regulation
|
CDH1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275654 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 26212009 |
The p21-activated kinase 5 (PAK5) is overexpressed in advanced cancer and the transcription factor E47 is a direct repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT). |In this study, we found that PAK5-mediated E47 phosphorylation promoted EMT in advanced colon cancer. PAK5 interacted with E47 and phosphorylated E47 on Ser39 under hepatocyte growth factor (HGF) stimulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates quantity by destabilization
phosphorylation
|
TCF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270009 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 14592976 |
Notch-induced degradation requires phosphorylation of E47 by p42/p44 MAP kinases. |Wild_type E47 but not the Mm mutant reacted to the antibodies, suggesting that E47 is at least phosphorylated at the M2 site (Figure 3A)|anti_phospho_M2 peptide (SSPSpTPVGSPQG) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ID1 | down-regulates activity
binding
|
TCF3 |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241107 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9242638 |
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TCF3 | down-regulates quantity by repression 
transcriptional regulation
|
BBC3 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23684607 |
The transcription factor TCF3, also known as E2A, drives p21 expression while repressing PUMA across cancer cell types of multiple origins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF3 | up-regulates activity
binding
|
MYOD1 |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-20540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1649701 |
In addition we demonstrate that myod, in conjunction with e12/e47-like proteins, is functioning as a regulatory nodal point for activation of several other downstream muscle regulators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
ERK1/2 | down-regulates quantity by destabilization
phosphorylation
|
TCF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270139 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 14592976 |
Notch-induced degradation requires phosphorylation of E47 by p42/p44 MAP kinases. |Wild_type E47 but not the Mm mutant reacted to the antibodies, suggesting that E47 is at least phosphorylated at the M2 site (Figure 3A)|anti_phospho_M2 peptide (SSPSpTPVGSPQG) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NOTCH1 | down-regulates
binding
|
TCF3 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56150 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9528794 |
We provide evidence that notch and deltex may act on e47 by inhibiting signaling through ras because (i) full e47 activity was found to be dependent on ras and (ii) both notch and deltex inhibited gal4-jun, a hybrid transcription factor whose activity is dependent on signaling from ras to sapk/jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID3 | down-regulates activity
binding
|
TCF3 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241134 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9242638 |
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TCF3 | form complex 
binding
|
MYOD/E12E47 |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241551 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18094043 |
MyoD omodimers or heterodimers of MyoD plus E12 or E47 serve as transcription factor complexes that bind to CANNTG consensus sites in the promoter regions of genes, performing major functions in specification and differentiation of skeletl muscle precursor cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
RANBP17 | up-regulates
binding
|
TCF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20503194 |
Yeast two-hybrid, mammalian two-hybrid, and co-immunoprecipitation analyses demonstrate specific interaction of e12 with ranbp17, a novel member of the importin-beta superfamily;this interaction maps to the crm1 homology region of ranbp17. Ectopic expression of ranbp17 leads to a approximately 3-fold increase in e2a/myod mediated transactivation of an e-box regulated luciferase reporter gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF3 | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1A |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255385 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23684607 |
The transcription factor TCF3, also known as E2A, drives p21 expression while repressing PUMA across cancer cell types of multiple origins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DTX1 | down-regulates
|
TCF3 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56141 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9528794 |
Our experiments indicate that deltex expression alone is suffcient to inhibit e47. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID2 | down-regulates activity
binding
|
TCF3 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241140 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9242638 |
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MSC | down-regulates activity
binding
|
TCF3 |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241315 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9584154 |
ABF-1 contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47 in mammalian cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPKAPK2 | up-regulates
phosphorylation
|
TCF3 |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166643 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Neverthless, some transcription factors, such as e47, er81, srf and creb are also phosphorylated by mk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1E | up-regulates
phosphorylation
|
TCF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11524435 |
Tcf3 is a substrate for both glycogen synthase kinase (gsk) 3 and casein kinase (ck) 1epsilon, and phosphorylation of tcf3 by ckiepsilon stimulates its binding to beta-catenin, an effect reversed by gsk3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF3 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH1 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197523 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22577461 |
E2a positively regulates notch1 expression, which induces the expression of hebalt, bcl11b, and il7r. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KRAS | up-regulates
phosphorylation
|
TCF3 |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56144 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9528794 |
Our results are consistent with a model in which notch and deltex act on e47 by inhibiting signaling through ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF3 | down-regulates quantity by repression
transcriptional regulation
|
CR2 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255387 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11739509 |
We have previously described the presence of an intronic element that is required for both cell- and stage-specific expression of CR2. In this study, we report the identification of a cell type-specific repressor element within the proximal promoter. By supershift analysis this element binds members of the basic helix-loop-helix family of proteins, in particular E2A gene products. Mutational analysis demonstrates that binding of E2A proteins is critical for functioning of this repressor. Thus, E2A activity is key not only for early B cell development, but also for controlling CR2 expression, a gene expressed only during later stages of ontogeny. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TCF3
- 
- 