| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | TCF3 | Thr355 | NFSSSPStPVGSPQG | phosphorylation down-regulates quantity by destabilization | 14592976 | SIGNOR-249451 |
| MAP3K10 | TCF3 | Thr355 | NFSSSPStPVGSPQG | phosphorylation down-regulates | 19801649 | SIGNOR-161544 |
| MAPK3 | TCF3 | Thr355 | NFSSSPStPVGSPQG | phosphorylation down-regulates quantity by destabilization | 14592976 | SIGNOR-249117 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | TCF3 PThr355 | phosphorylation down-regulates ⊣ | TCF3 | 14592976 | SIGNOR-249451 |
| MAP3K10 | phosphorylation up-regulates → | TCF3 PThr355 | phosphorylation down-regulates ⊣ | TCF3 | 19801649 | SIGNOR-161544 |
| MAPK3 | phosphorylation up-regulates → | TCF3 PThr355 | phosphorylation down-regulates ⊣ | TCF3 | 14592976 | SIGNOR-249117 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation![]() down-regulates quantity by destabilization | TCF3 | SIGNOR-249451 |
| MAP3K10 | phosphorylation![]() down-regulates | TCF3 | SIGNOR-161544 |
| MAPK3 | phosphorylation![]() down-regulates quantity by destabilization | TCF3 | SIGNOR-249117 |