| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates activity | 20921231 | SIGNOR-278457 |
| MAPK8 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates | 19234442 | SIGNOR-184146 |
| ATM | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates | 21690091 | SIGNOR-174442 |
| ATM | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates | 18158901 | SIGNOR-160206 |
| PPM1D | H2AX | Ser140 | GKKATQAsQEY | dephosphorylation down-regulates | 20118229 | SIGNOR-163693 |
| RPS6KA3 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates activity | 21224359 | SIGNOR-279349 |
| ATR | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates activity | 27442013 | SIGNOR-279356 |
| VRK1 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates activity | 25923214 | SIGNOR-278370 |
| MAPK9 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates | 18158901 | SIGNOR-160210 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 20921231 | SIGNOR-278457 |
| MAPK8 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 19234442 | SIGNOR-184146 |
| ATM | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 21690091 | SIGNOR-174442 |
| ATM | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 18158901 | SIGNOR-160206 |
| PPM1D | dephosphorylation down-regulates ⊣ | H2AX PSer140 | dephosphorylation up-regulates → | H2AX | 20118229 | SIGNOR-163693 |
| RPS6KA3 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 21224359 | SIGNOR-279349 |
| ATR | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 27442013 | SIGNOR-279356 |
| VRK1 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 25923214 | SIGNOR-278370 |
| MAPK9 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 18158901 | SIGNOR-160210 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation → up-regulates activity | H2AX | SIGNOR-278457 |
| MAPK8 | phosphorylation → up-regulates | H2AX | SIGNOR-184146 |
| ATM | phosphorylation → up-regulates | H2AX | SIGNOR-174442 |
| ATM | phosphorylation → up-regulates | H2AX | SIGNOR-160206 |
| PPM1D | dephosphorylation down-regulates | H2AX | SIGNOR-163693 |
| RPS6KA3 | phosphorylation → up-regulates activity | H2AX | SIGNOR-279349 |
| ATR | phosphorylation → up-regulates activity | H2AX | SIGNOR-279356 |
| VRK1 | phosphorylation → up-regulates activity | H2AX | SIGNOR-278370 |
| MAPK9 | phosphorylation → up-regulates | H2AX | SIGNOR-160210 |
