Relation Results

Summary

Name H2AX
Full Name Histone H2AX
Synonyms H2a/x, Histone H2A.X | H2AX
Primary ID P16104
Links - -
Type protein
Relations 22
Pathways FLT3-ITD signaling
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessib ...
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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.2DZIP3H2AXRNF168ATMSTK4VRK1MAPK8PPM1DMAPK9EYA3EYA1BAZ1BSLBPRNF8NatAMDC1BMI1NBNKDM4CBRCA1-BARD1 complexPRKDCUBE2N

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ DZIP3up-regulates activity img/direct-activation.png monoubiquitination H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271752 Lys119 IQAVLLPkKTSATVG Homo sapiens HEK-293 Cell
pmid sentence
 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation.
Publications: 1 Organism: Homo Sapiens
+ RNF168 img/unknown.png ubiquitination H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262063 Lys14 TGGKARAkAKSRSSR Homo sapiens
pmid sentence
We find that K63 ubiquitin chains are conjugated to RNF168-dependent H2A/H2AX monoubiquitination at K13-15 and not on K118-119.
Publications: 1 Organism: Homo Sapiens
+ ATMup-regulates img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-174442 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
Upon dna damage, h2ax is phosphorylated by ataxia telangiectasia mutated (atm) and atm-related kinases at serine 139, known as ?_?_?_-H2ax, which serves as a docking site to recruit the mediator of dna damage checkpoint protein 1 (mdc1) to sites of dna damage, named dna damage foci
Identifier Residue Sequence Organism Cell Line
SIGNOR-160206 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
H2ax interacts with numerous proteins required for dna damage signaling and repair when phosphorylated on ser-140. Phosphorylation of ser-140 (h2ax139ph) in response to ionizing radiation is mediated by both atm and prkdc. Our data showed that h2ax is phosphorylated by uva-activated jnk.
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ STK4up-regulates activity img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278457 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
Western blot and kinase assay results with a mutant S139A H2AX confirmed that MST1 phosphorylates H2AX at Ser-139.
Publications: 1 Organism: Homo Sapiens
+ VRK1up-regulates activity img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278370 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
In response to DNA damage induced by ionizing radiation, histone H2AX is phosphorylated in Ser139 by VRK1.
Publications: 1 Organism: Homo Sapiens
+ MAPK8up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-184146 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
The stress-response kinase jnk1, activated by dna damage and initiating a pro-apoptotic program, has been recently shown to translocate into the nucleus upon activation where it phosphorylates substrates including h2ax s139, an event critical for dna degradation mediated by caspase-activated dnase (cad) in apoptotic cells
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ PPM1Ddown-regulates img/direct_inhibition.png dephosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-163693 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-h2ax and suppresses dna double strand break repair. Here, we demonstrate that the wild-type p53-induced phosphatase 1 (wip1) also dephosphorylates gamma-h2ax at serine 139 in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ MAPK9up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-160210 Ser140 GKKATQAsQEY Homo sapiens
pmid sentence
H2ax interacts with numerous proteins required for dna damage signaling and repair when phosphorylated on ser-140. Phosphorylation of ser-140 (h2ax139ph) in response to ionizing radiation is mediated by both atm and prkdc. Our data showed that h2ax is phosphorylated by uva-activated jnk.
Publications: 1 Organism: Homo Sapiens
+ EYA3down-regulates img/direct_inhibition.png dephosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-168927 Tyr143 ATQASQEy Homo sapiens
pmid sentence
Tyr142 is dephosphorylated by the tyr phosphatases eya1 and eya3.
Publications: 1 Organism: Homo Sapiens
+ EYA1down-regulates img/direct_inhibition.png dephosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-168879 Tyr143 ATQASQEy Homo sapiens
pmid sentence
Tyr142 is dephosphorylated by the tyr phosphatases eya1 and eya3.
Publications: 1 Organism: Homo Sapiens
+ BAZ1Bup-regulates img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-182831 Tyr143 ATQASQEy Homo sapiens
pmid sentence
We show that wstf phosphorylates tyr 142 of h2a.x, and that wstf activity has an important role in regulating several events that are critical for the dna damage response
Publications: 1 Organism: Homo Sapiens
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265405 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
+ RNF8up-regulates img/direct-activation.png ubiquitination H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-159309 Homo sapiens
pmid sentence
Rnf8 can ubiquitylate histone h2a and h2ax,
Publications: 1 Organism: Homo Sapiens
+ NatAdown-regulates activity img/direct_inhibition.png acetylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267227 Homo sapiens HCT-116 Cell
pmid sentence
The human protein N(α)-terminal acetyltransferase A complex (hNatA), composed of the catalytic hNaa10p (hArd1) and auxiliary hNaa15p (hNat1/NATH/Tubedown) subunits, was reported to be important for cell survival and growth of various types of cancer.  lack of acetylation by hNatA activated H2A.X and Chk2 in both HCT116 cell lines independent of TP53 status (Fig. 6).
Publications: 1 Organism: Homo Sapiens
+ H2AXup-regulates img/direct-activation.png binding MDC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-143377 Homo sapiens
pmid sentence
Here, we demonstrate that mammalian mdc1/nfbd1 directly binds to phospho-h2ax (gammah2ax) by specifically interacting with the phosphoepitope at the gammah2ax carboxyl terminus.
Publications: 1 Organism: Homo Sapiens
+ BMI1up-regulates activity img/direct-activation.png ubiquitination H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278744 Homo sapiens
pmid sentence
In this process, BMI1 ubiquitinates histone H2A and \u03b3H2AX, thereby facilitating the repair of double-stranded DNA breaks through stimulating homologous recombination and non-homologous end joining.
Publications: 1 Organism: Homo Sapiens
+ H2AXup-regulates img/direct-activation.png binding NBN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-133020 Homo sapiens
pmid sentence
Nbs1 physically interacts with ?-H2ax to form nuclear foci at dna damage sites. The inhibition of this interaction by introduction of anti-?-H2ax antibody into cells abolishes nbs1 foci formation in response to dna damage.
Publications: 1 Organism: Homo Sapiens
+ KDM4Cdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263872 Homo sapiens
pmid sentence
Knockdown of JMJD2C gene led to the up-regulation of basal γ-H2AX expression. and γ-H2AX together with its phosphorylated C-terminal (Sre residues 139–140, γ-H2AX) are crucial for DNA repair
Publications: 1 Organism: Homo Sapiens
+ BRCA1-BARD1 complexup-regulates activity img/direct-activation.png ubiquitination H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263235 in vitro
pmid sentence
Strikingly, as well as H2AX, the nucleosome core histones H2A, H2B, H3 and H4 were all ubiquitylated efficiently by BRCA1/BARD1, while the linker histone H1 was not (Figure 3).| Generally, histone proteins are required for compaction of nuclear DNA into chromatin, and their modification is thought to loosen this compaction. Therefore, one might envisage that ubiquitylation of γH2AX by BRCA1/BARD1 at DNA breaks modulates local chromatin packaging to facilitate the action of DNA repair enzymes.
Publications: 1 Organism: In Vitro
+ PRKDCup-regulates img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-192443 Homo sapiens
pmid sentence
Dna-dependentprotein_ kinase_ (dna-pk) that phosphorylate h2ax at dsbs
Publications: 1 Organism: Homo Sapiens
+ UBE2Nup-regulates img/direct-activation.png ubiquitination H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-159880 Homo sapiens
pmid sentence
In an h2ax- and mdc1-dependent manner , rnf8/ubc13 complexes go to sites of dna damage through their fha domain and initiate the synthesis of k63 polyubiquitin chains on chromatin that recruit the brca1 a complex through the uim domains of rap80.
Publications: 1 Organism: Homo Sapiens
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