Summary

Name H2AFX
Full Name Histone H2AX
Synonyms H2a/x, Histone H2A.X | H2AX
Primary ID P16104
Links - -
Type protein
Relations 13
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation H2AFX
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AFX 0.11
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation H2AFX 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation H2AFX 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation H2AFX 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation H2AFX 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AFX 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MDC1 0.87
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AFX 0.74
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination H2AFX
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination H2AFX 0.50
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NBN
Publications: 1 Organism: Homo Sapiens