| Name | CREB1 |
| ID | P16220 |
| Role | substrate |
| Enzymatic Domains |
KID 87-146 PROSITE-ProRule
bZIP 269-327 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | CREB1 | Ser119 | EILSRRPsYRKILND | dephosphorylation down-regulates activity | 21385900 | SIGNOR-248543 |
| PRKACA | CREB1 | – | phosphorylation up-regulates activity | 15568017 | SIGNOR-131307 | |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17389598 | SIGNOR-153944 |
| CAMK2A | CREB1 | Ser142 | RKILNDLsSDAPGVP | phosphorylation down-regulates | 9668047 | SIGNOR-59137 |
| AKT2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9829964 | SIGNOR-62253 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8887554 | SIGNOR-44384 |
| GSK3B | CREB1 | Ser129 | QKRREILsRRPSYRK | phosphorylation up-regulates activity | 12162494 | SIGNOR-251233 |
| RPS6KA5 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9687510 | SIGNOR-59458 |
| CAMK4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17389598 | SIGNOR-153940 |
| TSSK4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 15964553 | SIGNOR-138289 |
| DYRK1A | CREB1 | – | phosphorylation up-regulates activity | 22110360 | SIGNOR-279989 | |
| CSNK1A1 | CREB1 | Ser94 | QISTIAEsEDSQESV | phosphorylation up-regulates | 9931297 | SIGNOR-64250 |
| RPS6KA1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 10558990 | SIGNOR-72117 |
| CDK5 | CREB1 | – | phosphorylation up-regulates activity | 29742423 | SIGNOR-279682 | |
| PRKACA | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8336722 | SIGNOR-166342 |
| ATM | CREB1 | Ser107 | SVDSVTDsQKRREIL | phosphorylation down-regulates | 15073328 | SIGNOR-124047 |
| RPS6KA3 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8688081 | SIGNOR-248951 |
| CSNK1A1 | CREB1 | Ser97 | TIAESEDsQESVDSV | phosphorylation up-regulates activity | 9931297 | SIGNOR-64254 |
| PRKACA | CREB1 | – | phosphorylation up-regulates activity | 21902831 | SIGNOR-176560 | |
| PRKACA | CREB1 | – | phosphorylation up-regulates activity | 15568017 | SIGNOR-255799 | |
| AKT1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-252549 |
| ATM | CREB1 | Thr100 | LKRLFSGtQISTIAE | phosphorylation down-regulates | 15073328 | SIGNOR-124051 |
| PRKG1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation unknown | 11175347 | SIGNOR-249076 |
| AKT | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-251474 |
| RPS6KA4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17668895 | SIGNOR-157158 |
| CAMK4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 12835716 | SIGNOR-102722 |
| CAMK2A | CREB1 | Ser142 | RKILNDLsSDAPGVP | phosphorylation down-regulates | 11013247 | SIGNOR-82501 |
| PKA | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8386317 | SIGNOR-263653 |
| RPS6K | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 10558990 | SIGNOR-252782 |
| CAMK2A | CREB1 | Ser142 | RKILNDLsSDAPGVP | phosphorylation down-regulates | 11970864 | SIGNOR-117344 |
| AKT | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-247992 |
| ATM | CREB1 | Ser97 | TIAESEDsQESVDSV | phosphorylation down-regulates activity | 15073328 | SIGNOR-124043 |
| ATR | CREB1 | Ser107 | SVDSVTDsQKRREIL | phosphorylation down-regulates | 15073328 | SIGNOR-124060 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 20626350 | SIGNOR-166619 |
| CSNK1A1 | CREB1 | Ser100 | ESEDSQEsVDSVTDS | phosphorylation up-regulates | 9931297 | SIGNOR-64258 |
| AKT3 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9829964 | SIGNOR-62257 |
| HIPK2 | CREB1 | Ser257 | PGVVMASsPALPTQP | phosphorylation up-regulates | 20573984 | SIGNOR-166338 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | CREB1 PSer119 | dephosphorylation up-regulates → | CREB1 | 21385900 | SIGNOR-248543 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17389598 | SIGNOR-153944 |
| CAMK2A | phosphorylation up-regulates → | CREB1 PSer142 | phosphorylation down-regulates ⊣ | CREB1 | 9668047 | SIGNOR-59137 |
| AKT2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-62253 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8887554 | SIGNOR-44384 |
| GSK3B | phosphorylation up-regulates → | CREB1 PSer129 | phosphorylation up-regulates → | CREB1 | 12162494 | SIGNOR-251233 |
| RPS6KA5 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9687510 | SIGNOR-59458 |
| CAMK4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17389598 | SIGNOR-153940 |
| TSSK4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 15964553 | SIGNOR-138289 |
| CSNK1A1 | phosphorylation up-regulates → | CREB1 PSer94 | phosphorylation up-regulates → | CREB1 | 9931297 | SIGNOR-64250 |
| RPS6KA1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 10558990 | SIGNOR-72117 |
| PRKACA | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8336722 | SIGNOR-166342 |
| ATM | phosphorylation up-regulates → | CREB1 PSer107 | phosphorylation down-regulates ⊣ | CREB1 | 15073328 | SIGNOR-124047 |
| RPS6KA3 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8688081 | SIGNOR-248951 |
| CSNK1A1 | phosphorylation up-regulates → | CREB1 PSer97 | phosphorylation up-regulates → | CREB1 | 9931297 | SIGNOR-64254 |
| AKT1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-252549 |
| ATM | phosphorylation up-regulates → | CREB1 PThr100 | phosphorylation down-regulates ⊣ | CREB1 | 15073328 | SIGNOR-124051 |
| PRKG1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation down-regulates ⊣ | CREB1 | 11175347 | SIGNOR-249076 |
| AKT | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-251474 |
| RPS6KA4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17668895 | SIGNOR-157158 |
| CAMK4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 12835716 | SIGNOR-102722 |
| CAMK2A | phosphorylation up-regulates → | CREB1 PSer142 | phosphorylation down-regulates ⊣ | CREB1 | 11013247 | SIGNOR-82501 |
| PKA | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8386317 | SIGNOR-263653 |
| RPS6K | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 10558990 | SIGNOR-252782 |
| CAMK2A | phosphorylation up-regulates → | CREB1 PSer142 | phosphorylation down-regulates ⊣ | CREB1 | 11970864 | SIGNOR-117344 |
| AKT | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-247992 |
| ATM | phosphorylation up-regulates → | CREB1 PSer97 | phosphorylation down-regulates ⊣ | CREB1 | 15073328 | SIGNOR-124043 |
| ATR | phosphorylation up-regulates → | CREB1 PSer107 | phosphorylation down-regulates ⊣ | CREB1 | 15073328 | SIGNOR-124060 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 20626350 | SIGNOR-166619 |
| CSNK1A1 | phosphorylation up-regulates → | CREB1 PSer100 | phosphorylation up-regulates → | CREB1 | 9931297 | SIGNOR-64258 |
| AKT3 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-62257 |
| HIPK2 | phosphorylation up-regulates → | CREB1 PSer257 | phosphorylation up-regulates → | CREB1 | 20573984 | SIGNOR-166338 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → down-regulates activity | CREB1 | SIGNOR-248543 |
| PRKACA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-131307 |
| MAPKAPK2 | phosphorylation → up-regulates | CREB1 | SIGNOR-153944 |
| CAMK2A | phosphorylation down-regulates | CREB1 | SIGNOR-59137 |
| AKT2 | phosphorylation → up-regulates | CREB1 | SIGNOR-62253 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-44384 |
| GSK3B | phosphorylation → up-regulates activity | CREB1 | SIGNOR-251233 |
| RPS6KA5 | phosphorylation → up-regulates | CREB1 | SIGNOR-59458 |
| CAMK4 | phosphorylation → up-regulates | CREB1 | SIGNOR-153940 |
| TSSK4 | phosphorylation → up-regulates | CREB1 | SIGNOR-138289 |
| DYRK1A | phosphorylation → up-regulates activity | CREB1 | SIGNOR-279989 |
| CSNK1A1 | phosphorylation → up-regulates | CREB1 | SIGNOR-64250 |
| RPS6KA1 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-72117 |
| CDK5 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-279682 |
| PRKACA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-166342 |
| ATM | phosphorylation down-regulates | CREB1 | SIGNOR-124047 |
| RPS6KA3 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-248951 |
| CSNK1A1 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-64254 |
| PRKACA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-176560 |
| PRKACA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-255799 |
| AKT1 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-252549 |
| ATM | phosphorylation down-regulates | CREB1 | SIGNOR-124051 |
| PRKG1 | phosphorylation → unknown | CREB1 | SIGNOR-249076 |
| AKT | phosphorylation → up-regulates activity | CREB1 | SIGNOR-251474 |
| RPS6KA4 | phosphorylation → up-regulates | CREB1 | SIGNOR-157158 |
| CAMK4 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-102722 |
| CAMK2A | phosphorylation down-regulates | CREB1 | SIGNOR-82501 |
| PKA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-263653 |
| RPS6K | phosphorylation → up-regulates activity | CREB1 | SIGNOR-252782 |
| CAMK2A | phosphorylation down-regulates | CREB1 | SIGNOR-117344 |
| AKT | phosphorylation → up-regulates activity | CREB1 | SIGNOR-247992 |
| ATM | phosphorylation → down-regulates activity | CREB1 | SIGNOR-124043 |
| ATR | phosphorylation down-regulates | CREB1 | SIGNOR-124060 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-166619 |
| CSNK1A1 | phosphorylation → up-regulates | CREB1 | SIGNOR-64258 |
| AKT3 | phosphorylation → up-regulates | CREB1 | SIGNOR-62257 |
| HIPK2 | phosphorylation → up-regulates | CREB1 | SIGNOR-166338 |