Summary

Name CREB1
Full Name Cyclic AMP-responsive element-binding protein 1
Synonyms CREB-1, cAMP-responsive element-binding protein 1
Primary ID P16220
Links - -
Type protein
Relations 71
Pathways AMPK Signaling, P38 Signaling, WNT Signaling, WNT Signaling and Myogenesis, Glioblastoma Multiforme, Malignant Melanoma, Inhibition of Apoptosis, Adipogenesis
Function Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CREB1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.22
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:AMPK Signaling, Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png dephosphorylation CREB1 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Glioblastoma Multiforme, Malignant Melanoma
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.48
Publications: 4 Organism: Rattus Norvegicus, Homo Sapiens, Mus Musculus
Tissue: Skeletal Muscle, Myotome
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma, P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CREB1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.31
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Inhibition of Apoptosis
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CREB1 0.23
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PCK1 0.14
Publications: 1 Organism: Pongo Pygmaeus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UXT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PAX3 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.34
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR4A3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CREB1 0.46
Publications: 1 Organism: Pongo Pygmaeus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CHGA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREB1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MITF 0.22
Publications: 1
Pathways:Malignant Melanoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCSK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PKM 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation PPARGC1A 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Liver
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNNB1 0.28
Publications: 1 Organism: Xenopus Laevis
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FST 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding FOXO 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PLAT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR2F6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FOXO4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Survival 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, Inhibition of Apoptosis, Malignant Melanoma, WNT Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MUC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Malignant Melanoma
+ up-regulates quantity img/direct-activation.png transcriptional regulation G6PC 0.14
Publications: 1 Organism: Pongo Pygmaeus