| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | CREB1 | Ser97 | TIAESEDsQESVDSV | phosphorylation down-regulates activity | 15073328 | SIGNOR-124043 |
| CSNK1A1 | CREB1 | Ser97 | TIAESEDsQESVDSV | phosphorylation up-regulates activity | 9931297 | SIGNOR-64254 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | CREB1 PSer97 | phosphorylation down-regulates ⊣ | CREB1 | 15073328 | SIGNOR-124043 |
| CSNK1A1 | phosphorylation up-regulates → | CREB1 PSer97 | phosphorylation up-regulates → | CREB1 | 9931297 | SIGNOR-64254 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → down-regulates activity | CREB1 | SIGNOR-124043 |
| CSNK1A1 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-64254 |