| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8386317 | SIGNOR-263653 |
| RPS6K | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 10558990 | SIGNOR-252782 |
| AKT | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-247992 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 20626350 | SIGNOR-166619 |
| AKT3 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9829964 | SIGNOR-62257 |
| RPS6KA5 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9687510 | SIGNOR-59458 |
| TSSK4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 15964553 | SIGNOR-138289 |
| RPS6KA1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 10558990 | SIGNOR-72117 |
| PTEN | CREB1 | Ser119 | EILSRRPsYRKILND | dephosphorylation down-regulates activity | 21385900 | SIGNOR-248543 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17389598 | SIGNOR-153944 |
| AKT2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9829964 | SIGNOR-62253 |
| MAPKAPK2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8887554 | SIGNOR-44384 |
| CAMK4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17389598 | SIGNOR-153940 |
| PRKACA | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8336722 | SIGNOR-166342 |
| RPS6KA3 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 8688081 | SIGNOR-248951 |
| AKT1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-252549 |
| PRKG1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation unknown | 11175347 | SIGNOR-249076 |
| AKT | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-251474 |
| RPS6KA4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17668895 | SIGNOR-157158 |
| CAMK4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 12835716 | SIGNOR-102722 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8386317 | SIGNOR-263653 |
| RPS6K | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 10558990 | SIGNOR-252782 |
| AKT | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-247992 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 20626350 | SIGNOR-166619 |
| AKT3 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-62257 |
| RPS6KA5 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9687510 | SIGNOR-59458 |
| TSSK4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 15964553 | SIGNOR-138289 |
| RPS6KA1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 10558990 | SIGNOR-72117 |
| PTEN | dephosphorylation down-regulates ⊣ | CREB1 PSer119 | dephosphorylation up-regulates → | CREB1 | 21385900 | SIGNOR-248543 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17389598 | SIGNOR-153944 |
| AKT2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-62253 |
| MAPKAPK2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8887554 | SIGNOR-44384 |
| CAMK4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17389598 | SIGNOR-153940 |
| PRKACA | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8336722 | SIGNOR-166342 |
| RPS6KA3 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 8688081 | SIGNOR-248951 |
| AKT1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-252549 |
| PRKG1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation down-regulates ⊣ | CREB1 | 11175347 | SIGNOR-249076 |
| AKT | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-251474 |
| RPS6KA4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17668895 | SIGNOR-157158 |
| CAMK4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 12835716 | SIGNOR-102722 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-263653 |
| RPS6K | phosphorylation → up-regulates activity | CREB1 | SIGNOR-252782 |
| AKT | phosphorylation → up-regulates activity | CREB1 | SIGNOR-247992 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-166619 |
| AKT3 | phosphorylation → up-regulates | CREB1 | SIGNOR-62257 |
| RPS6KA5 | phosphorylation → up-regulates | CREB1 | SIGNOR-59458 |
| TSSK4 | phosphorylation → up-regulates | CREB1 | SIGNOR-138289 |
| RPS6KA1 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-72117 |
| PTEN | dephosphorylation → down-regulates activity | CREB1 | SIGNOR-248543 |
| MAPKAPK2 | phosphorylation → up-regulates | CREB1 | SIGNOR-153944 |
| AKT2 | phosphorylation → up-regulates | CREB1 | SIGNOR-62253 |
| MAPKAPK2 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-44384 |
| CAMK4 | phosphorylation → up-regulates | CREB1 | SIGNOR-153940 |
| PRKACA | phosphorylation → up-regulates activity | CREB1 | SIGNOR-166342 |
| RPS6KA3 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-248951 |
| AKT1 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-252549 |
| PRKG1 | phosphorylation → unknown | CREB1 | SIGNOR-249076 |
| AKT | phosphorylation → up-regulates activity | CREB1 | SIGNOR-251474 |
| RPS6KA4 | phosphorylation → up-regulates | CREB1 | SIGNOR-157158 |
| CAMK4 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-102722 |
