Entity Details

Name PDGFRA
ID P16234
Role kinase
Enzymatic Domains
Ig-like C2-type 1 24-113
Ig-like C2-type 2 117-201
Ig-like C2-type 3 202-306
Ig-like C2-type 4 319-410
Ig-like C2-type 5 414-517
Protein kinase 593-954
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PDGFRASRCTyr419RLIEDNEyTARQGAKphosphorylation
up-regulates activity		15489898SIGNOR-247984
PDGFRAPDGFRATyr1018RLSADSGyIIPLPDIphosphorylation
up-regulates activity		7535778SIGNOR-250250
PDGFRAPDGFRATyr988RVDSDNAyIGVTYKNphosphorylation
up-regulates activity		7535778SIGNOR-250252
PDGFRAPDGFRATyr762SDIQRSLyDRPASYKphosphorylation
up-regulates activity		9546424SIGNOR-249716
PDGFRAPLCG1–phosphorylation
up-regulates		7535778SIGNOR-28176
PDGFRAPTK2Tyr194ALEKKSNyEVLEKDVphosphorylation
up-regulates activity		20802513SIGNOR-259400
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDGFRAphosphorylation
up-regulates
→
SRC
PTyr419		phosphorylation
up-regulates
→		SRC15489898SIGNOR-247984
PDGFRAphosphorylation
up-regulates
→
PDGFRA
PTyr1018		phosphorylation
up-regulates
→		PDGFRA7535778SIGNOR-250250
PDGFRAphosphorylation
up-regulates
→
PDGFRA
PTyr988		phosphorylation
up-regulates
→		PDGFRA7535778SIGNOR-250252
PDGFRAphosphorylation
up-regulates
→
PDGFRA
PTyr762		phosphorylation
up-regulates
→		PDGFRA9546424SIGNOR-249716
PDGFRAphosphorylation
up-regulates
→
PTK2
PTyr194		phosphorylation
up-regulates
→		PTK220802513SIGNOR-259400
Regulator Mechanism/Effect Target SIGNOR-ID
PDGFRAphosphorylation
→
up-regulates activity 		SRCSIGNOR-247984
PDGFRAphosphorylation
→
up-regulates activity 		PDGFRASIGNOR-250250
PDGFRAphosphorylation
→
up-regulates activity 		PDGFRASIGNOR-250252
PDGFRAphosphorylation
→
up-regulates activity 		PDGFRASIGNOR-249716
PDGFRAphosphorylation
→
up-regulates 		PLCG1SIGNOR-28176
PDGFRAphosphorylation
→
up-regulates activity 		PTK2SIGNOR-259400