Summary

Name PDGFRA
Full Name Platelet-derived growth factor receptor alpha
Synonyms PDGF-R-alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2 | PDGFR2, RHEPDGFRA
Primary ID P16234
Links - -
Type protein
Relations 32
Pathways Rhabdomyosarcoma
Inhibitors Sunitinib malate; Crenolanib; Linifanib; axitinib; ; canertinib; imatinib; masitinib; nilotinib; tandutinib; Imatinib; nintedanib; Amuvatinib
Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PDGFRA 0.34
Publications: 3 Organism: Sus Scrofa
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.51
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png dephosphorylation PDGFRA 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRA 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PDGFRA 0.57
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding PDGFRA 0.58
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung
Pathways:Rhabdomyosarcoma
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PDGFRA 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CRK 0.55
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 1 Organism: In Vitro
+ down-regulates activity img/indirect_inhibition.png chemical inhibition PDGFRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRA 0
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PLCG1 0.56
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown ERK1/2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma