Entity Details

Name PDGFRA
ID P16234
Role substrate
Enzymatic Domains
Ig-like C2-type 1 24-113
Ig-like C2-type 2 117-201
Ig-like C2-type 3 202-306
Ig-like C2-type 4 319-410
Ig-like C2-type 5 414-517
Protein kinase 593-954
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPRGPDGFRATyr754ERKEVSKySDIQRSLdephosphorylation
up-regulates activity		25624455SIGNOR-254714
PDGFRAPDGFRATyr762SDIQRSLyDRPASYKphosphorylation
up-regulates activity		9546424SIGNOR-249716
PDGFRAPDGFRATyr988RVDSDNAyIGVTYKNphosphorylation
up-regulates activity		7535778SIGNOR-250252
PDGFRAPDGFRATyr1018RLSADSGyIIPLPDIphosphorylation
up-regulates activity		7535778SIGNOR-250250
PTPRGPDGFRATyr742KQADTTQyVPMLERKdephosphorylation
up-regulates activity		25624455SIGNOR-254713
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPRGdephosphorylation
down-regulates
⊣
PDGFRA
PTyr754		dephosphorylation
down-regulates
⊣		PDGFRA25624455SIGNOR-254714
PDGFRAphosphorylation
up-regulates
→
PDGFRA
PTyr762		phosphorylation
up-regulates
→		PDGFRA9546424SIGNOR-249716
PDGFRAphosphorylation
up-regulates
→
PDGFRA
PTyr988		phosphorylation
up-regulates
→		PDGFRA7535778SIGNOR-250252
PDGFRAphosphorylation
up-regulates
→
PDGFRA
PTyr1018		phosphorylation
up-regulates
→		PDGFRA7535778SIGNOR-250250
PTPRGdephosphorylation
down-regulates
⊣
PDGFRA
PTyr742		dephosphorylation
down-regulates
⊣		PDGFRA25624455SIGNOR-254713
Regulator Mechanism/Effect Target SIGNOR-ID
PTPRGdephosphorylation
→
up-regulates activity 		PDGFRASIGNOR-254714
PDGFRAphosphorylation
→
up-regulates activity 		PDGFRASIGNOR-249716
PDGFRAphosphorylation
→
up-regulates activity 		PDGFRASIGNOR-250252
PDGFRAphosphorylation
→
up-regulates activity 		PDGFRASIGNOR-250250
PTPRGdephosphorylation
→
up-regulates activity 		PDGFRASIGNOR-254713