| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | HMGA1 | Ser103 | EGISQESsEEEQ | phosphorylation unknown | 2806554 | SIGNOR-251005 |
| CDK2 | HMGA1 | Ser36 | PRKQPPVsPGTALVG | phosphorylation down-regulates | 17960875 | SIGNOR-158612 |
| CSNK2A1 | HMGA1 | Ser99 | KEEEEGIsQESSEEE | phosphorylation unknown | 2806554 | SIGNOR-250894 |
| CDK1 | HMGA1 | Ser36 | PRKQPPVsPGTALVG | phosphorylation down-regulates | 17960875 | SIGNOR-158604 |
| CSNK2A1 | HMGA1 | Ser102 | EEGISQEsSEEEQ | phosphorylation unknown | 2806554 | SIGNOR-250892 |
| PRKCD | HMGA1 | Ser44 | PGTALVGsQKEPSEV | phosphorylation down-regulates | 10617144 | SIGNOR-73606 |
| CSNK2A2 | HMGA1 | Ser99 | KEEEEGIsQESSEEE | phosphorylation unknown | 2806554 | SIGNOR-251006 |
| CSNK2A1 | HMGA1 | Ser103 | EGISQESsEEEQ | phosphorylation unknown | 2806554 | SIGNOR-250893 |
| PRKCD | HMGA1 | Ser64 | PRGRPKGsKNKGAAK | phosphorylation down-regulates | 10617144 | SIGNOR-73610 |
| HIPK2 | HMGA1 | Ser36 | PRKQPPVsPGTALVG | phosphorylation down-regulates | 17960875 | SIGNOR-158616 |
| CDK1 | HMGA1 | Thr53 | KEPSEVPtPKRPRGR | phosphorylation down-regulates | 17960875 | SIGNOR-158608 |
| ATM | HMGA1 | – | phosphorylation up-regulates activity | 18783938 | SIGNOR-279493 | |
| HIPK2 | HMGA1 | Thr53 | KEPSEVPtPKRPRGR | phosphorylation down-regulates | 17960875 | SIGNOR-158620 |
| CDK1 | HMGA1 | Thr78 | KTRKTTTtPGRKPRG | phosphorylation down-regulates | 1939057 | SIGNOR-22338 |
| CSNK2A2 | HMGA1 | Ser102 | EEGISQEsSEEEQ | phosphorylation unknown | 2806554 | SIGNOR-251004 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | phosphorylation up-regulates → | HMGA1 PSer103 | phosphorylation down-regulates ⊣ | HMGA1 | 2806554 | SIGNOR-251005 |
| CDK2 | phosphorylation up-regulates → | HMGA1 PSer36 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158612 |
| CSNK2A1 | phosphorylation up-regulates → | HMGA1 PSer99 | phosphorylation down-regulates ⊣ | HMGA1 | 2806554 | SIGNOR-250894 |
| CDK1 | phosphorylation up-regulates → | HMGA1 PSer36 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158604 |
| CSNK2A1 | phosphorylation up-regulates → | HMGA1 PSer102 | phosphorylation down-regulates ⊣ | HMGA1 | 2806554 | SIGNOR-250892 |
| PRKCD | phosphorylation up-regulates → | HMGA1 PSer44 | phosphorylation down-regulates ⊣ | HMGA1 | 10617144 | SIGNOR-73606 |
| CSNK2A2 | phosphorylation up-regulates → | HMGA1 PSer99 | phosphorylation down-regulates ⊣ | HMGA1 | 2806554 | SIGNOR-251006 |
| CSNK2A1 | phosphorylation up-regulates → | HMGA1 PSer103 | phosphorylation down-regulates ⊣ | HMGA1 | 2806554 | SIGNOR-250893 |
| PRKCD | phosphorylation up-regulates → | HMGA1 PSer64 | phosphorylation down-regulates ⊣ | HMGA1 | 10617144 | SIGNOR-73610 |
| HIPK2 | phosphorylation up-regulates → | HMGA1 PSer36 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158616 |
| CDK1 | phosphorylation up-regulates → | HMGA1 PThr53 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158608 |
| HIPK2 | phosphorylation up-regulates → | HMGA1 PThr53 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158620 |
| CDK1 | phosphorylation up-regulates → | HMGA1 PThr78 | phosphorylation down-regulates ⊣ | HMGA1 | 1939057 | SIGNOR-22338 |
| CSNK2A2 | phosphorylation up-regulates → | HMGA1 PSer102 | phosphorylation down-regulates ⊣ | HMGA1 | 2806554 | SIGNOR-251004 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A2 | phosphorylation → unknown | HMGA1 | SIGNOR-251005 |
| CDK2 | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-158612 |
| CSNK2A1 | phosphorylation → unknown | HMGA1 | SIGNOR-250894 |
| CDK1 | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-158604 |
| CSNK2A1 | phosphorylation → unknown | HMGA1 | SIGNOR-250892 |
| PRKCD | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-73606 |
| CSNK2A2 | phosphorylation → unknown | HMGA1 | SIGNOR-251006 |
| CSNK2A1 | phosphorylation → unknown | HMGA1 | SIGNOR-250893 |
| PRKCD | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-73610 |
| HIPK2 | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-158616 |
| CDK1 | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-158608 |
| ATM | phosphorylation → up-regulates activity | HMGA1 | SIGNOR-279493 |
| HIPK2 | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-158620 |
| CDK1 | phosphorylation![]() down-regulates | HMGA1 | SIGNOR-22338 |
| CSNK2A2 | phosphorylation → unknown | HMGA1 | SIGNOR-251004 |