Summary

Name HMGA1
Full Name High mobility group protein HMG-I/HMG-Y
Synonyms HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein A1, High mobility group protein R | HMGIY
Primary ID P17096
Links - -
Type protein
Relations 18
Function HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation HMGA1 0.14
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation HMGA1 0.14
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.35
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.28
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization HMGA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding POU3F1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KITLG 0.14
Publications: 1 Organism: Homo Sapiens