| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-144465 |
| CSNK1D | GJA1 | Ser330 | AGSTISNsHAQPFDF | phosphorylation up-regulates activity | 12270943 | SIGNOR-249331 |
| PTPN2 | GJA1 | Tyr247 | VKGKSDPyHATSGAL | dephosphorylation up-regulates | 24849651 | SIGNOR-205097 |
| MAPK3 | GJA1 | Ser282 | TAPLSPMsPPGYKLV | phosphorylation down-regulates activity | 9535909 | SIGNOR-249467 |
| PTPN2 | GJA1 | Tyr265 | KDCGSQKyAYFNGCS | dephosphorylation up-regulates | 24849651 | SIGNOR-205101 |
| MAPK7 | GJA1 | Ser255 | HATSGALsPAKDCGS | phosphorylation down-regulates activity | 12637502 | SIGNOR-250115 |
| PRKCA | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249048 |
| SRC | GJA1 | Tyr247 | VKGKSDPyHATSGAL | phosphorylation down-regulates | 16916748 | SIGNOR-148913 |
| MAPK3 | GJA1 | Ser279 | SSPTAPLsPMSPPGY | phosphorylation down-regulates activity | 9535909 | SIGNOR-249466 |
| MAPK1 | GJA1 | Ser279 | SSPTAPLsPMSPPGY | phosphorylation down-regulates activity | 9535909 | SIGNOR-249402 |
| PRKCB | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249049 |
| CSNK1D | GJA1 | Ser328 | GQAGSTIsNSHAQPF | phosphorylation up-regulates activity | 12270943 | SIGNOR-249330 |
| MAPK1 | GJA1 | Ser282 | TAPLSPMsPPGYKLV | phosphorylation down-regulates activity | 9535909 | SIGNOR-249403 |
| CSNK1D | GJA1 | Ser325 | NRMGQAGsTISNSHA | phosphorylation up-regulates activity | 12270943 | SIGNOR-249329 |
| MAPK1 | GJA1 | Ser255 | HATSGALsPAKDCGS | phosphorylation down-regulates activity | 9535909 | SIGNOR-249401 |
| PRKCG | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249050 |
| PRKCE | GJA1 | Ser369 | RPSSRASsRASSRPR | phosphorylation up-regulates | 16474210 | SIGNOR-144469 |
| MAPK3 | GJA1 | Ser255 | HATSGALsPAKDCGS | phosphorylation down-regulates activity | 9535909 | SIGNOR-249465 |
| PRKCE | GJA1 | Ser365 | IVDQRPSsRASSRAS | phosphorylation up-regulates | 16474210 | SIGNOR-144461 |
| PRKCA | GJA1 | Ser262 | SPAKDCGsQKYAYFN | phosphorylation down-regulates | 14702389 | SIGNOR-120907 |
| PRKCE | GJA1 | Ser373 | RASSRASsRPRPDDL | phosphorylation up-regulates | 16474210 | SIGNOR-144473 |
| Gbeta | GJA1 | – | phosphorylation down-regulates activity | 9535909 | SIGNOR-270025 | |
| ERK1/2 | GJA1 | – | phosphorylation down-regulates activity | 9535909 | SIGNOR-270148 | |
| SRC | GJA1 | Tyr265 | KDCGSQKyAYFNGCS | phosphorylation down-regulates | 16916748 | SIGNOR-148917 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-144465 |
| CSNK1D | phosphorylation up-regulates → | GJA1 PSer330 | phosphorylation up-regulates → | GJA1 | 12270943 | SIGNOR-249331 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GJA1 PTyr247 | dephosphorylation down-regulates ⊣ | GJA1 | 24849651 | SIGNOR-205097 |
| MAPK3 | phosphorylation up-regulates → | GJA1 PSer282 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249467 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GJA1 PTyr265 | dephosphorylation down-regulates ⊣ | GJA1 | 24849651 | SIGNOR-205101 |
| MAPK7 | phosphorylation up-regulates → | GJA1 PSer255 | phosphorylation down-regulates ⊣ | GJA1 | 12637502 | SIGNOR-250115 |
| PRKCA | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249048 |
| SRC | phosphorylation up-regulates → | GJA1 PTyr247 | phosphorylation down-regulates ⊣ | GJA1 | 16916748 | SIGNOR-148913 |
| MAPK3 | phosphorylation up-regulates → | GJA1 PSer279 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249466 |
| MAPK1 | phosphorylation up-regulates → | GJA1 PSer279 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249402 |
| PRKCB | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249049 |
| CSNK1D | phosphorylation up-regulates → | GJA1 PSer328 | phosphorylation up-regulates → | GJA1 | 12270943 | SIGNOR-249330 |
| MAPK1 | phosphorylation up-regulates → | GJA1 PSer282 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249403 |
| CSNK1D | phosphorylation up-regulates → | GJA1 PSer325 | phosphorylation up-regulates → | GJA1 | 12270943 | SIGNOR-249329 |
| MAPK1 | phosphorylation up-regulates → | GJA1 PSer255 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249401 |
| PRKCG | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249050 |
| PRKCE | phosphorylation up-regulates → | GJA1 PSer369 | phosphorylation up-regulates → | GJA1 | 16474210 | SIGNOR-144469 |
| MAPK3 | phosphorylation up-regulates → | GJA1 PSer255 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249465 |
| PRKCE | phosphorylation up-regulates → | GJA1 PSer365 | phosphorylation up-regulates → | GJA1 | 16474210 | SIGNOR-144461 |
| PRKCA | phosphorylation up-regulates → | GJA1 PSer262 | phosphorylation down-regulates ⊣ | GJA1 | 14702389 | SIGNOR-120907 |
| PRKCE | phosphorylation up-regulates → | GJA1 PSer373 | phosphorylation up-regulates → | GJA1 | 16474210 | SIGNOR-144473 |
| SRC | phosphorylation up-regulates → | GJA1 PTyr265 | phosphorylation down-regulates ⊣ | GJA1 | 16916748 | SIGNOR-148917 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCE | phosphorylation → down-regulates activity | GJA1 | SIGNOR-144465 |
| CSNK1D | phosphorylation → up-regulates activity | GJA1 | SIGNOR-249331 |
| PTPN2 | dephosphorylation → up-regulates | GJA1 | SIGNOR-205097 |
| MAPK3 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249467 |
| PTPN2 | dephosphorylation → up-regulates | GJA1 | SIGNOR-205101 |
| MAPK7 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-250115 |
| PRKCA | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249048 |
| SRC | phosphorylation down-regulates | GJA1 | SIGNOR-148913 |
| MAPK3 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249466 |
| MAPK1 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249402 |
| PRKCB | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249049 |
| CSNK1D | phosphorylation → up-regulates activity | GJA1 | SIGNOR-249330 |
| MAPK1 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249403 |
| CSNK1D | phosphorylation → up-regulates activity | GJA1 | SIGNOR-249329 |
| MAPK1 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249401 |
| PRKCG | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249050 |
| PRKCE | phosphorylation → up-regulates | GJA1 | SIGNOR-144469 |
| MAPK3 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249465 |
| PRKCE | phosphorylation → up-regulates | GJA1 | SIGNOR-144461 |
| PRKCA | phosphorylation down-regulates | GJA1 | SIGNOR-120907 |
| PRKCE | phosphorylation → up-regulates | GJA1 | SIGNOR-144473 |
| Gbeta | phosphorylation → down-regulates activity | GJA1 | SIGNOR-270025 |
| ERK1/2 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-270148 |
| SRC | phosphorylation down-regulates | GJA1 | SIGNOR-148917 |
