| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | GJA1 | Ser255 | HATSGALsPAKDCGS | phosphorylation down-regulates activity | 9535909 | SIGNOR-249465 |
| MAPK1 | GJA1 | Ser255 | HATSGALsPAKDCGS | phosphorylation down-regulates activity | 9535909 | SIGNOR-249401 |
| MAPK7 | GJA1 | Ser255 | HATSGALsPAKDCGS | phosphorylation down-regulates activity | 12637502 | SIGNOR-250115 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | GJA1 PSer255 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249465 |
| MAPK1 | phosphorylation up-regulates → | GJA1 PSer255 | phosphorylation down-regulates ⊣ | GJA1 | 9535909 | SIGNOR-249401 |
| MAPK7 | phosphorylation up-regulates → | GJA1 PSer255 | phosphorylation down-regulates ⊣ | GJA1 | 12637502 | SIGNOR-250115 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249465 |
| MAPK1 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249401 |
| MAPK7 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-250115 |