| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-144465 |
| PRKCB | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249049 |
| PRKCG | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249050 |
| PRKCA | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249048 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-144465 |
| PRKCB | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249049 |
| PRKCG | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249050 |
| PRKCA | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249048 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCE | phosphorylation → down-regulates activity | GJA1 | SIGNOR-144465 |
| PRKCB | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249049 |
| PRKCG | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249050 |
| PRKCA | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249048 |