Entity Details

Name CAPN2
ID P17655
Role substrate
Enzymatic Domains
Calpain catalytic 45-344
PROSITE-ProRule
EF-hand 1 572-605
PROSITE-ProRule
EF-hand 2 602-637
PROSITE-ProRule
EF-hand 3 667-700
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SRCCAPN2Tyr625RSGTMNSyEMRKALEphosphorylation
up-regulates activity		35697802SIGNOR-277598
MAPK3CAPN2Ser50GTLFQDPsFPAIPSAphosphorylation
up-regulates		14993287SIGNOR-123083
MAPK1CAPN2Ser50GTLFQDPsFPAIPSAphosphorylation
up-regulates		14993287SIGNOR-123079
ERK1/2CAPN2–phosphorylation
up-regulates		14993287SIGNOR-270179
GbetaCAPN2–phosphorylation
up-regulates		14993287SIGNOR-270078
PRKACACAPN2Thr370GNWRRGStAGGCRNYphosphorylation
down-regulates		11909964SIGNOR-116248
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRCphosphorylation
up-regulates
→
CAPN2
PTyr625		phosphorylation
up-regulates
→		CAPN235697802SIGNOR-277598
MAPK3phosphorylation
up-regulates
→
CAPN2
PSer50		phosphorylation
up-regulates
→		CAPN214993287SIGNOR-123083
MAPK1phosphorylation
up-regulates
→
CAPN2
PSer50		phosphorylation
up-regulates
→		CAPN214993287SIGNOR-123079
PRKACAphosphorylation
up-regulates
→
CAPN2
PThr370		phosphorylation
down-regulates
⊣		CAPN211909964SIGNOR-116248
Regulator Mechanism/Effect Target SIGNOR-ID
SRCphosphorylation
→
up-regulates activity 		CAPN2SIGNOR-277598
MAPK3phosphorylation
→
up-regulates 		CAPN2SIGNOR-123083
MAPK1phosphorylation
→
up-regulates 		CAPN2SIGNOR-123079
ERK1/2phosphorylation
→
up-regulates 		CAPN2SIGNOR-270179
Gbetaphosphorylation
→
up-regulates 		CAPN2SIGNOR-270078
PRKACAphosphorylation
img/direct_inhibition.png
down-regulates 		CAPN2SIGNOR-116248