| Name | CAPN2 |
| ID | P17655 |
| Role | substrate |
| Enzymatic Domains |
Calpain catalytic 45-344 PROSITE-ProRule
EF-hand 1 572-605 PROSITE-ProRule
EF-hand 2 602-637 PROSITE-ProRule
EF-hand 3 667-700 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Gbeta | CAPN2 | – | phosphorylation up-regulates | 14993287 | SIGNOR-270078 | |
| PRKACA | CAPN2 | Thr370 | GNWRRGStAGGCRNY | phosphorylation down-regulates | 11909964 | SIGNOR-116248 |
| MAPK1 | CAPN2 | Ser50 | GTLFQDPsFPAIPSA | phosphorylation up-regulates | 14993287 | SIGNOR-123079 |
| MAPK3 | CAPN2 | Ser50 | GTLFQDPsFPAIPSA | phosphorylation up-regulates | 14993287 | SIGNOR-123083 |
| SRC | CAPN2 | Tyr625 | RSGTMNSyEMRKALE | phosphorylation up-regulates activity | 35697802 | SIGNOR-277598 |
| ERK1/2 | CAPN2 | – | phosphorylation up-regulates | 14993287 | SIGNOR-270179 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | CAPN2 PThr370 | phosphorylation down-regulates ⊣ | CAPN2 | 11909964 | SIGNOR-116248 |
| MAPK1 | phosphorylation up-regulates → | CAPN2 PSer50 | phosphorylation up-regulates → | CAPN2 | 14993287 | SIGNOR-123079 |
| MAPK3 | phosphorylation up-regulates → | CAPN2 PSer50 | phosphorylation up-regulates → | CAPN2 | 14993287 | SIGNOR-123083 |
| SRC | phosphorylation up-regulates → | CAPN2 PTyr625 | phosphorylation up-regulates → | CAPN2 | 35697802 | SIGNOR-277598 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| Gbeta | phosphorylation → up-regulates | CAPN2 | SIGNOR-270078 |
| PRKACA | phosphorylation down-regulates | CAPN2 | SIGNOR-116248 |
| MAPK1 | phosphorylation → up-regulates | CAPN2 | SIGNOR-123079 |
| MAPK3 | phosphorylation → up-regulates | CAPN2 | SIGNOR-123083 |
| SRC | phosphorylation → up-regulates activity | CAPN2 | SIGNOR-277598 |
| ERK1/2 | phosphorylation → up-regulates | CAPN2 | SIGNOR-270179 |