| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | NCL | Thr84 | PAKKAAVtPGKKAAA | dephosphorylation up-regulates activity | 28332494 | SIGNOR-277166 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | NCL PThr84 | dephosphorylation down-regulates ⊣ | NCL | 28332494 | SIGNOR-277166 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → up-regulates activity | NCL | SIGNOR-277166 |