Summary

Name NCL
Full Name Nucleolin
Synonyms Protein C23
Primary ID P19338
Links - -
Type protein
Relations 3
Function Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding MYB 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYBL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png translation regulation HBB 0.14
Publications: 1 Organism: Homo Sapiens