| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | ELK1 | Thr336 | GGPGPERtPGSGSGS | phosphorylation up-regulates | 7889942 | SIGNOR-235467 |
| MAPK3 | ELK1 | – | phosphorylation up-regulates | 7618106 | SIGNOR-29923 | |
| ERK1/2 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 7889942 | SIGNOR-252083 |
| MAPK1 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates activity | 7889942 | SIGNOR-235455 |
| ERK1/2 | ELK1 | – | phosphorylation up-regulates | 7618106 | SIGNOR-252081 | |
| MAPK3 | ELK1 | Ser422 | LSTPVVLsPGPQKP | phosphorylation up-regulates | 7889942 | SIGNOR-34665 |
| MAPK1 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 7889942 | SIGNOR-235471 |
| AKT | ELK1 | – | phosphorylation up-regulates activity | 22085529 | SIGNOR-259029 | |
| Gbeta | ELK1 | – | phosphorylation up-regulates | 7889942 | SIGNOR-270075 | |
| ERK1/2 | ELK1 | Ser422 | LSTPVVLsPGPQKP | phosphorylation up-regulates | 7889942 | SIGNOR-252084 |
| MAPK14 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 11145955 | SIGNOR-85510 |
| MAPK14 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 20727996 | SIGNOR-167539 |
| TAOK2 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates activity | 12665513 | SIGNOR-246638 |
| MAPK3 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 7889942 | SIGNOR-34657 |
| RPS6KA5 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 11145955 | SIGNOR-85514 |
| MAPK14 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 9130707 | SIGNOR-47630 |
| MAPK14 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 9130707 | SIGNOR-47634 |
| MAPK8 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 8846788 | SIGNOR-44356 |
| MAPK8 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 7651411 | SIGNOR-236432 |
| MAPK1 | ELK1 | Ser422 | LSTPVVLsPGPQKP | phosphorylation up-regulates activity | 7889942 | SIGNOR-235463 |
| ERK1/2 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 7889942 | SIGNOR-252086 |
| ERK1/2 | ELK1 | Ser324 | RDLELPLsPSLLGGP | phosphorylation up-regulates | 7889942 | SIGNOR-252085 |
| PRPF4B | ELK1 | Thr417 | ISVDGLStPVVLSPG | phosphorylation up-regulates | 10799319 | SIGNOR-77135 |
| MAPK3 | ELK1 | Thr336 | GGPGPERtPGSGSGS | phosphorylation up-regulates | 7889942 | SIGNOR-34669 |
| MAPK3 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 7889942 | SIGNOR-34661 |
| ERK1/2 | ELK1 | Thr336 | GGPGPERtPGSGSGS | phosphorylation up-regulates | 7889942 | SIGNOR-252082 |
| ERK1/2 | ELK1 | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-233520 | |
| MAPK3 | ELK1 | Ser324 | RDLELPLsPSLLGGP | phosphorylation up-regulates | 7889942 | SIGNOR-34653 |
| MAPK8 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 8846788 | SIGNOR-236455 |
| MAPK1 | ELK1 | Ser324 | RDLELPLsPSLLGGP | phosphorylation up-regulates activity | 7889942 | SIGNOR-235459 |
| MAPK9 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 8846788 | SIGNOR-247062 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | ELK1 PThr336 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-235467 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252083 |
| MAPK1 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-235455 |
| MAPK3 | phosphorylation up-regulates → | ELK1 PSer422 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-34665 |
| MAPK1 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-235471 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer422 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252084 |
| MAPK14 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 11145955 | SIGNOR-85510 |
| MAPK14 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 20727996 | SIGNOR-167539 |
| TAOK2 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 12665513 | SIGNOR-246638 |
| MAPK3 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-34657 |
| RPS6KA5 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 11145955 | SIGNOR-85514 |
| MAPK14 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 9130707 | SIGNOR-47630 |
| MAPK14 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 9130707 | SIGNOR-47634 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-44356 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7651411 | SIGNOR-236432 |
| MAPK1 | phosphorylation up-regulates → | ELK1 PSer422 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-235463 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252086 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer324 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252085 |
| PRPF4B | phosphorylation up-regulates → | ELK1 PThr417 | phosphorylation up-regulates → | ELK1 | 10799319 | SIGNOR-77135 |
| MAPK3 | phosphorylation up-regulates → | ELK1 PThr336 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-34669 |
| MAPK3 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-34661 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PThr336 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252082 |
| MAPK3 | phosphorylation up-regulates → | ELK1 PSer324 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-34653 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-236455 |
| MAPK1 | phosphorylation up-regulates → | ELK1 PSer324 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-235459 |
| MAPK9 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-247062 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | ELK1 | SIGNOR-235467 |
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-29923 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252083 |
| MAPK1 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-235455 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252081 |
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-34665 |
| MAPK1 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-235471 |
| AKT | phosphorylation → up-regulates activity | ELK1 | SIGNOR-259029 |
| Gbeta | phosphorylation → up-regulates | ELK1 | SIGNOR-270075 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252084 |
| MAPK14 | phosphorylation → up-regulates | ELK1 | SIGNOR-85510 |
| MAPK14 | phosphorylation → up-regulates | ELK1 | SIGNOR-167539 |
| TAOK2 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-246638 |
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-34657 |
| RPS6KA5 | phosphorylation → up-regulates | ELK1 | SIGNOR-85514 |
| MAPK14 | phosphorylation → up-regulates | ELK1 | SIGNOR-47630 |
| MAPK14 | phosphorylation → up-regulates | ELK1 | SIGNOR-47634 |
| MAPK8 | phosphorylation → up-regulates | ELK1 | SIGNOR-44356 |
| MAPK8 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-236432 |
| MAPK1 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-235463 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252086 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252085 |
| PRPF4B | phosphorylation → up-regulates | ELK1 | SIGNOR-77135 |
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-34669 |
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-34661 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252082 |
| ERK1/2 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-233520 |
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-34653 |
| MAPK8 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-236455 |
| MAPK1 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-235459 |
| MAPK9 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-247062 |
