Summary

Name ELK1
Full Name ETS domain-containing protein Elk-1
Synonyms ELK1_HUMAN
Primary ID P19419
Links - -
Type protein
Relations 36
Pathways EGFR, SAPK/JNK Signaling, Glioblastoma Multiforme, IL6 , Noonan syndrome, Integrin Signalling
Function Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.42
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.36
Publications: 4 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.43
Publications: 6 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, IL6 , Integrin Signalling, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.4
Publications: 4 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.42
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.36
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Lung
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png phosphorylation ELK1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Integrin Signalling
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.43
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, IL6 , Integrin Signalling, Noonan syndrome
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MUC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ELK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ELK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell Growth 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, IL6 , Integrin Signalling