| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 7889942 | SIGNOR-34661 |
| MAPK8 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 8846788 | SIGNOR-236455 |
| MAPK9 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 8846788 | SIGNOR-247062 |
| MAPK1 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 7889942 | SIGNOR-235471 |
| MAPK14 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 9130707 | SIGNOR-47634 |
| MAPK8 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 7651411 | SIGNOR-236432 |
| ERK1/2 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 7889942 | SIGNOR-252086 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-34661 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-236455 |
| MAPK9 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-247062 |
| MAPK1 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-235471 |
| MAPK14 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 9130707 | SIGNOR-47634 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7651411 | SIGNOR-236432 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252086 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | ELK1 | SIGNOR-34661 |
| MAPK8 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-236455 |
| MAPK9 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-247062 |
| MAPK1 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-235471 |
| MAPK14 | phosphorylation → up-regulates | ELK1 | SIGNOR-47634 |
| MAPK8 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-236432 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252086 |
