| Name | TFEB |
| ID | P19484 |
| Role | substrate |
| Enzymatic Domains |
bHLH 235-288 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | TFEB | Ser109 | NKFAAHIsPAQGSPK | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277881 |
| CDK6 | TFEB | – | phosphorylation up-regulates activity | 32662822 | SIGNOR-279454 | |
| PPP2CA | TFEB | Ser122 | PKPPPAAsPGVRAGH | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277878 |
| mTORC1 | TFEB | Ser142 | AGNSAPNsPMAMLHI | phosphorylation down-regulates activity | 22343943 | SIGNOR-255309 |
| PRKCB | TFEB | Ser466 | SKASSRRsSFSMEEG | phosphorylation up-regulates activity | 23599343 | SIGNOR-255315 |
| MAP4K3 | TFEB | Ser3 | sRIGLRMQ | phosphorylation down-regulates activity | 29507340 | SIGNOR-278282 |
| PPP2CA | TFEB | Ser114 | HISPAQGsPKPPPAA | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277880 |
| MAPK1 | TFEB | Ser142 | AGNSAPNsPMAMLHI | phosphorylation down-regulates activity | 21617040 | SIGNOR-248279 |
| PRKCB | TFEB | Ser467 | KASSRRSsFSMEEGD | phosphorylation up-regulates activity | 23599343 | SIGNOR-255316 |
| MTOR | TFEB | Ser211 | LVGVTSSsCPADLTQ | phosphorylation down-regulates activity | 22692423 | SIGNOR-248270 |
| MTOR | TFEB | Ser142 | AGNSAPNsPMAMLHI | phosphorylation down-regulates activity | 22343943 | SIGNOR-255310 |
| ABL1 | TFEB | – | phosphorylation down-regulates activity | 33163944 | SIGNOR-279583 | |
| PPP3CB | TFEB | Ser142 | AGNSAPNsPMAMLHI | dephosphorylation up-regulates activity | 26000950 | SIGNOR-255307 |
| PPP2CA | TFEB | Ser211 | LVGVTSSsCPADLTQ | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277879 |
| PPP3CB | TFEB | Ser211 | LVGVTSSsCPADLTQ | dephosphorylation up-regulates activity | 26000950 | SIGNOR-255306 |
| CDK4 | TFEB | – | phosphorylation up-regulates activity | 32662822 | SIGNOR-279450 | |
| mTORC1 | TFEB | Ser211 | LVGVTSSsCPADLTQ | phosphorylation down-regulates activity | 22692423 | SIGNOR-248274 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer109 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277881 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer122 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277878 |
| mTORC1 | phosphorylation up-regulates → | TFEB PSer142 | phosphorylation down-regulates ⊣ | TFEB | 22343943 | SIGNOR-255309 |
| PRKCB | phosphorylation up-regulates → | TFEB PSer466 | phosphorylation up-regulates → | TFEB | 23599343 | SIGNOR-255315 |
| MAP4K3 | phosphorylation up-regulates → | TFEB PSer3 | phosphorylation down-regulates ⊣ | TFEB | 29507340 | SIGNOR-278282 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer114 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277880 |
| MAPK1 | phosphorylation up-regulates → | TFEB PSer142 | phosphorylation down-regulates ⊣ | TFEB | 21617040 | SIGNOR-248279 |
| PRKCB | phosphorylation up-regulates → | TFEB PSer467 | phosphorylation up-regulates → | TFEB | 23599343 | SIGNOR-255316 |
| MTOR | phosphorylation up-regulates → | TFEB PSer211 | phosphorylation down-regulates ⊣ | TFEB | 22692423 | SIGNOR-248270 |
| MTOR | phosphorylation up-regulates → | TFEB PSer142 | phosphorylation down-regulates ⊣ | TFEB | 22343943 | SIGNOR-255310 |
| PPP3CB | dephosphorylation down-regulates ⊣ | TFEB PSer142 | dephosphorylation down-regulates ⊣ | TFEB | 26000950 | SIGNOR-255307 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer211 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277879 |
| PPP3CB | dephosphorylation down-regulates ⊣ | TFEB PSer211 | dephosphorylation down-regulates ⊣ | TFEB | 26000950 | SIGNOR-255306 |
| mTORC1 | phosphorylation up-regulates → | TFEB PSer211 | phosphorylation down-regulates ⊣ | TFEB | 22692423 | SIGNOR-248274 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277881 |
| CDK6 | phosphorylation → up-regulates activity | TFEB | SIGNOR-279454 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277878 |
| mTORC1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-255309 |
| PRKCB | phosphorylation → up-regulates activity | TFEB | SIGNOR-255315 |
| MAP4K3 | phosphorylation → down-regulates activity | TFEB | SIGNOR-278282 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277880 |
| MAPK1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-248279 |
| PRKCB | phosphorylation → up-regulates activity | TFEB | SIGNOR-255316 |
| MTOR | phosphorylation → down-regulates activity | TFEB | SIGNOR-248270 |
| MTOR | phosphorylation → down-regulates activity | TFEB | SIGNOR-255310 |
| ABL1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-279583 |
| PPP3CB | dephosphorylation → up-regulates activity | TFEB | SIGNOR-255307 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277879 |
| PPP3CB | dephosphorylation → up-regulates activity | TFEB | SIGNOR-255306 |
| CDK4 | phosphorylation → up-regulates activity | TFEB | SIGNOR-279450 |
| mTORC1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-248274 |