| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | TFEB | Ser211 | LVGVTSSsCPADLTQ | phosphorylation down-regulates activity | 22692423 | SIGNOR-248270 |
| PPP2CA | TFEB | Ser211 | LVGVTSSsCPADLTQ | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277879 |
| PPP3CB | TFEB | Ser211 | LVGVTSSsCPADLTQ | dephosphorylation up-regulates activity | 26000950 | SIGNOR-255306 |
| mTORC1 | TFEB | Ser211 | LVGVTSSsCPADLTQ | phosphorylation down-regulates activity | 22692423 | SIGNOR-248274 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | TFEB PSer211 | phosphorylation down-regulates ⊣ | TFEB | 22692423 | SIGNOR-248270 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer211 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277879 |
| PPP3CB | dephosphorylation down-regulates ⊣ | TFEB PSer211 | dephosphorylation down-regulates ⊣ | TFEB | 26000950 | SIGNOR-255306 |
| mTORC1 | phosphorylation up-regulates → | TFEB PSer211 | phosphorylation down-regulates ⊣ | TFEB | 22692423 | SIGNOR-248274 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → down-regulates activity | TFEB | SIGNOR-248270 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277879 |
| PPP3CB | dephosphorylation → up-regulates activity | TFEB | SIGNOR-255306 |
| mTORC1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-248274 |
