| Name | NFKB1 |
| ID | P19838 |
| Role | substrate |
| Enzymatic Domains |
RHD 42-367 PROSITE-ProRule
Death 805-892 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | NFKB1 | Ser328 | INITKPAsVFVQLRR | phosphorylation down-regulates | 22152481 | SIGNOR-195208 |
| IKBKB | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70465 |
| IKBKB | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates activity | 11158290 | SIGNOR-104807 |
| CHUK | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70457 |
| CHUK | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70449 |
| CHUK | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235438 |
| PRKACA | NFKB1 | Ser337 | FVQLRRKsDLETSEP | phosphorylation up-regulates | 17959673 | SIGNOR-158595 |
| GSK3B | NFKB1 | Ser903 | KTTSQAHsLPLSPAS | phosphorylation up-regulates quantity by stabilization | 12871932 | SIGNOR-251251 |
| CHUK | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235442 |
| IKBKB | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates activity | 11158290 | SIGNOR-104811 |
| IKBKB | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates activity | 11158290 | SIGNOR-104803 |
| IKBKB | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70469 |
| GSK3B | NFKB1 | Ser907 | QAHSLPLsPASTRQQ | phosphorylation up-regulates quantity by stabilization | 12871932 | SIGNOR-251252 |
| PRKACA | NFKB1 | Ser937 | ETSFRKLsFTESLTS | phosphorylation up-regulates quantity by stabilization | 19531803 | SIGNOR-260327 |
| CHUK | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70453 |
| IKBKB | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70473 |
| CHUK | NFKB1 | Thr931 | VCDSGVEtSFRKLSF | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70461 |
| CHUK | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235434 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | NFKB1 PSer328 | phosphorylation down-regulates ⊣ | NFKB1 | 22152481 | SIGNOR-195208 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70465 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104807 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70457 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70449 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235438 |
| PRKACA | phosphorylation up-regulates → | NFKB1 PSer337 | phosphorylation up-regulates → | NFKB1 | 17959673 | SIGNOR-158595 |
| GSK3B | phosphorylation up-regulates → | NFKB1 PSer903 | phosphorylation up-regulates → | NFKB1 | 12871932 | SIGNOR-251251 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235442 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104811 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104803 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70469 |
| GSK3B | phosphorylation up-regulates → | NFKB1 PSer907 | phosphorylation up-regulates → | NFKB1 | 12871932 | SIGNOR-251252 |
| PRKACA | phosphorylation up-regulates → | NFKB1 PSer937 | phosphorylation up-regulates → | NFKB1 | 19531803 | SIGNOR-260327 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70453 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70473 |
| CHUK | phosphorylation up-regulates → | NFKB1 PThr931 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70461 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235434 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation down-regulates | NFKB1 | SIGNOR-195208 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70465 |
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104807 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70457 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70449 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235438 |
| PRKACA | phosphorylation → up-regulates | NFKB1 | SIGNOR-158595 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | NFKB1 | SIGNOR-251251 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235442 |
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104811 |
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104803 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70469 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | NFKB1 | SIGNOR-251252 |
| PRKACA | phosphorylation → up-regulates quantity by stabilization | NFKB1 | SIGNOR-260327 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70453 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70473 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70461 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235434 |