| + |
CHEK1 | down-regulates 
phosphorylation
|
NFKB1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195208 |
Ser328 |
INITKPAsVFVQLRR |
Homo sapiens |
|
| pmid |
sentence |
| 22152481 |
Taken together, the above findings suggest that chk1 phosphorylates p50 at s329 and further, that this phosphorylation blocks p50 dna binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates 
phosphorylation
|
NFKB1 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158595 |
Ser337 |
FVQLRRKsDLETSEP |
Homo sapiens |
|
| pmid |
sentence |
| 17959673 |
In this study, we demonstrate that the phosphorylation of p50 and p65 by the catalytic subunit of protein kinase a (pkac) is essential for nf-kappab dna binding and transactivation activity. treatment with h89 and knockdown of pkac in cells led to the inhibition of phosphorylation at p50 ser(337) and p65 ser(276) and loss of dna binding by nf-kappab. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates quantity by stabilization
phosphorylation
|
NFKB1 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251251 |
Ser903 |
KTTSQAHsLPLSPAS |
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 12871932 |
GSK-3 beta forms an in vivo complex with and specifically phosphorylates NF-kappa B1/p105 at Ser-903 and Ser-907 in vitro. GSK-3 beta has a dual effect on p105: it stabilizes p105 under resting conditions and primes p105 for degradation upon tumor necrosis factor (TNF)-alpha treatment. Indeed, constitutive processing of p105 to p50 occurs at a higher rate in cells lacking GSK-3 beta with respect to wild-type cells and can be reduced upon reintroduction of GSK-3 beta by transfection. S903A and S907A point mutations impair p105 proteolysis in response to TNF-α. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251252 |
Ser907 |
QAHSLPLsPASTRQQ |
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 12871932 |
GSK-3 beta forms an in vivo complex with and specifically phosphorylates NF-kappa B1/p105 at Ser-903 and Ser-907 in vitro. GSK-3 beta has a dual effect on p105: it stabilizes p105 under resting conditions and primes p105 for degradation upon tumor necrosis factor (TNF)-alpha treatment. Indeed, constitutive processing of p105 to p50 occurs at a higher rate in cells lacking GSK-3 beta with respect to wild-type cells and can be reduced upon reintroduction of GSK-3 beta by transfection. S903A and S907A point mutations impair p105 proteolysis in response to TNF-α. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
IKBKB | down-regulates quantity by destabilization
phosphorylation
|
NFKB1 |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70465 |
Ser923 |
DELRDSDsVCDSGVE |
Homo sapiens |
Fibrosarcoma Cell |
| pmid |
sentence |
| 10469655 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70469 |
Ser927 |
DSDSVCDsGVETSFR |
Homo sapiens |
Fibrosarcoma Cell |
| pmid |
sentence |
| 10469655 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70473 |
Ser932 |
CDSGVETsFRKLSFT |
Homo sapiens |
Fibrosarcoma Cell |
| pmid |
sentence |
| 10469655 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CHUK | down-regulates quantity by destabilization
phosphorylation
|
NFKB1 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235434 |
Ser923 |
DELRDSDsVCDSGVE |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11297557 |
The i b kinase (ikk) complex rapidly phosphorylates nf- b1 p105 on serine 927 in the pest region romashkova et al. demonstrated that akt binds to and activates inhibitor of kappa b kinase-alfa (ikkalfa), which in turn phosphorylates and thereby promotes the degradation of the inhibitory cofactor of nf-kb, i-kb the scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70449 |
Ser923 |
DELRDSDsVCDSGVE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10469655 |
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70453 |
Ser927 |
DSDSVCDsGVETSFR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10469655 |
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235438 |
Ser927 |
DSDSVCDsGVETSFR |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11297557 |
The i b kinase (ikk) complex rapidly phosphorylates nf- b1 p105 on serine 927 in the pest region romashkova et al. demonstrated that akt binds to and activates inhibitor of kappa b kinase-alfa (ikkalfa), which in turn phosphorylates and thereby promotes the degradation of the inhibitory cofactor of nf-kb, i-kb the scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235442 |
Ser932 |
CDSGVETsFRKLSFT |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11297557 |
The i b kinase (ikk) complex rapidly phosphorylates nf- b1 p105 on serine 927 in the pest region romashkova et al. demonstrated that akt binds to and activates inhibitor of kappa b kinase-alfa (ikkalfa), which in turn phosphorylates and thereby promotes the degradation of the inhibitory cofactor of nf-kb, i-kb the scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70457 |
Ser932 |
CDSGVETsFRKLSFT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10469655 |
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70461 |
Thr931 |
VCDSGVEtSFRKLSF |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10469655 |
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391). |
|
| Publications: |
7 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
IKBKB | down-regulates activity
phosphorylation
|
NFKB1 |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104803 |
Ser923 |
DELRDSDsVCDSGVE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11158290 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104807 |
Ser927 |
DSDSVCDsGVETSFR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11158290 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104811 |
Ser932 |
CDSGVETsFRKLSFT |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11158290 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates quantity by stabilization
phosphorylation
|
NFKB1 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260327 |
Ser937 |
ETSFRKLsFTESLTS |
|
|
| pmid |
sentence |
| 19531803 |
Ser940 of p105 was phosphorylated by PKA to a similar extent, whereas no phosphorylation of the same sequence occurred when Ser940 was substituted by Ala|Mechanistically, phosphorylation of p105 at Ser940 by PKA appeared to attenuate the extent of IKK-dependent phosphorylation of p105 at Ser935, which could in turn influence the rate of activation of NF-kappaB |
|
| Publications: |
1 |
| + |
NR3C1 | down-regulates quantity by repression
transcriptional regulation
|
NFKB1 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8639160 |
We have described how the receptor uses several means to achieve repression of the genes regulated by AP-1 and NF-KB proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
BTRC | down-regulates quantity by destabilization
polyubiquitination
|
NFKB1 |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272570 |
|
|
in vitro |
|
| pmid |
sentence |
| 10835356 |
Here we demonstrate that following IkappaB kinase (IkappaK)-mediated phosphorylation, the C-terminal domain of p105 (residues 918-934) serves as a recognition motif for the SCF(beta)(-TrCP) ubiquitin ligase.In vitro, SCF(beta)(-TrCP) specifically conjugates and promotes processing of phosphorylated p105. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NFKB1 | down-regulates quantity by repression 
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17211835 |
Blocking the transcriptional activation of NF-kappaB prevented the TNFalpha-induced downregulation of TM. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBX1 | up-regulates
ubiquitination
|
NFKB1 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11295495 |
The scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates quantity by expression 
transcriptional regulation
|
TRAF1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733516 |
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PERP | down-regulates quantity
ubiquitination
|
NFKB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25860612 |
We identify KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL10 | up-regulates quantity by expression
transcriptional regulation
|
NFKB1 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274145 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14695475 |
The adaptor protein Bcl10 promotes activation of NF-κB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | form complex 
binding
|
NfKb-p65/p50 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9450761 |
Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
CASP8AP2 | up-regulates
binding
|
NFKB1 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22075988 |
In addition, both cleavage products of c-flip turned out to be inducers of nf-kb activity by binding to the ikk complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
NFKB1 |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110963 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11591772 |
Nf-kappab activity is regulated by notch-1 via transcriptional control of nf-kappab. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
NFKB1 | down-regulates quantity by repression
transcriptional regulation
|
BMP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266086 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
The effect of TNF-alpha on the Bmp4 promoter is mediated through NF-kB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL3 | up-regulates activity
binding
|
NFKB1 |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254789 |
|
|
Homo sapiens |
Corneal Epithelial Cell |
| pmid |
sentence |
| 21912613 |
In the present study, we report that regulation of CTCF by extracellular stress signals is dependent upon activations of an oxidative stress-regulated protein Bcl-3. We found that activated Bcl-3 was able to bind to the κB sites identified in the CTCF promoter region. Bcl-3 was activated by UV irradiation to interact with NF-κB p50 by forming a Bcl-3/p50 heterodimer complex. The Bcl-3/p50 complex suppressed CTCF promoter activity to down-regulate CTCF transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POMC | down-regulates activity
|
NFKB1 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252371 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 16274845 |
Alpha-MSH is an anti-inflammatory peptide which signals by binding to the melanocortin-1 receptor (MC1R) and elevating cyclic AMP in several different cells and tissues. The carboxyl terminal peptides of alpha-MSH (KPV/GKPV) are the smallest minimal sequences that prevent inflammation, but it is not known if they operate via MC1R or cyclic AMP. Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates quantity by expression
transcriptional regulation
|
KLK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253668 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 11909978 |
NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | up-regulates
|
NFKB1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17604717 |
Several studies have demonstrated that akt signaling can activate the nf-kb transcription factor downstream of a variety of stimuli, such as tumor necrosis factor (tnfalfa) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates quantity by expression
transcriptional regulation
|
BIRC3 |
0.648 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733516 |
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKBIE | down-regulates
binding
|
NFKB1 |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102774 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
Nf-kb is normally sequestered in the cell cytoplasm by binding to ikbx, ikbb, ikbe |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF123 | down-regulates quantity by destabilization
polyubiquitination
|
NFKB1 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272221 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25860612 |
Here, we identify KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates activity
binding
|
RELA |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9450761 |
Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
NFKB1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217969 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
In mouse muscles, overexpression of PGC-1beta (like PGC-1alpha) inhibited denervation atrophy, ubiquitin ligase induction, and transcription by NFkappaB |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
NFKB1 |
transcriptional regulation
|
NPPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253648 |
|
|
|
|
| pmid |
sentence |
| 15837525 |
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. |
|
| Publications: |
1 |
| + |
NFKB1 | down-regulates
binding
|
MAP3K8 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22435554 |
Tpl-2 is stoichiometrically complexed with the nf-kb inhibitory protein, nf-kb1 p105, and the ubiquitin-binding protein abin-2, both of which are required to maintain tpl-2 protein stability. Binding to p105 also prevents tpl-2 from phosphorylating mek |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | down-regulates quantity by repression
transcriptional regulation
|
CTCF |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254788 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21912613 |
In the present study, we report that regulation of CTCF by extracellular stress signals is dependent upon activations of an oxidative stress-regulated protein Bcl-3. We found that activated Bcl-3 was able to bind to the κB sites identified in the CTCF promoter region. Bcl-3 was activated by UV irradiation to interact with NF-κB p50 by forming a Bcl-3/p50 heterodimer complex. The Bcl-3/p50 complex suppressed CTCF promoter activity to down-regulate CTCF transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKBIA | down-regulates activity
binding
|
NFKB1 |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-17688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1340770 |
Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates quantity by expression
transcriptional regulation
|
IEX-1L |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9703517 |
Transcription factors of the nuclear factor-kappab/rel (nf-kappab) family may be important in cell survival by regulating unidentified, anti-apoptotic genes. One such gene that protects cells from apoptosis induced by fas or tumor necrosis factor type alpha (tnf), iex-1l, is described here. Its transcription induced by tnf was decreased in cells with defective nf-kappab activation, rendering them sensitive to tnf-induced apoptosis, which was abolished by transfection with iex-1l. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | up-regulates activity
ubiquitination
|
NFKB1 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217190 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11295495 |
The scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NFKB1 | up-regulates quantity by expression
transcriptional regulation
|
BIRC2 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733516 |
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates quantity by expression
transcriptional regulation
|
CD80 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253934 |
|
|
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 12860928 |
Upon CD40 signaling, transcription of the CD80 gene is induced by the nuclear factor (NF)-kappaB transcription factor. Our results show that BCL6 prevents CD40-induced expression of CD80 by binding its promoter region in vivo and suppressing its transcriptional activation by NF-kappaB. Consistent with a physiologic role for BCL6 in suppressing CD80, the expression of these two genes is mutually exclusive in B cells, and BCL6-defective mice show increased expression of CD80 in B cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAP3K7 | up-regulates quantity by expression
transcriptional regulation
|
NFKB1 |
0.581 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55713 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9480845 |
These results suggest that tak1 induces nf-kappa b activation through a novel nik-independent signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BTF3 | down-regulates quantity by repression
transcriptional regulation
|
NFKB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17312387 |
In contrast, BTF3 silencing resulted in down-regulation of several cancer-associated genes, including EPHB2, ABL2, HPSE2 and ATM, and up-regulation of KRAG, RRAS2, NFkappa-B, MRVI1, MADCAM1 and others. In conclusion, BTF3 is overexpressed in PDAC, where it acts as a transcriptional regulator rather than a direct modulator of apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NFKB1
- 
- 