| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates activity | 11158290 | SIGNOR-104807 |
| CHUK | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235438 |
| IKBKB | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70469 |
| CHUK | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70453 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104807 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235438 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70469 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70453 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104807 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235438 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70469 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70453 |
