| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1B | HNF1A | Ser249 | IQRGVSPsQAQGLGS | phosphorylation up-regulates | 11980910 | SIGNOR-86728 |
| ATM | HNF1A | Ser249 | IQRGVSPsQAQGLGS | phosphorylation up-regulates | 24821553 | SIGNOR-205087 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1B | phosphorylation up-regulates → | HNF1A PSer249 | phosphorylation up-regulates → | HNF1A | 11980910 | SIGNOR-86728 |
| ATM | phosphorylation up-regulates → | HNF1A PSer249 | phosphorylation up-regulates → | HNF1A | 24821553 | SIGNOR-205087 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1B | phosphorylation → up-regulates | HNF1A | SIGNOR-86728 |
| ATM | phosphorylation → up-regulates | HNF1A | SIGNOR-205087 |
