| + |
DYRK1B | up-regulates 
phosphorylation
|
HNF1A |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86728 |
Ser249 |
IQRGVSPsQAQGLGS |
Homo sapiens |
|
| pmid |
sentence |
| 11980910 |
Mirk phosphorylates hnf1 at amino acid 249mkk3 enhanced mirk kinase activity and the transcriptional activation of hnf1alpha by mirk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
ATM | up-regulates
phosphorylation
|
HNF1A |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205087 |
Ser249 |
IQRGVSPsQAQGLGS |
Homo sapiens |
|
| pmid |
sentence |
| 24821553 |
Serine 249 phosphorylation by atm protein kinase regulates hepatocyte nuclear factor-1_ transactivation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression 
transcriptional regulation
|
AFP |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254637 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 7549116 |
HNF-1 beta was found to be more potent than HNF-1 alpha in activating the AFP promoter in the HepG2 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254435 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11314020 |
We investigated AFP gene regulation in AFP-GC by an active transcription factor, HNF1 (hepatocyte nuclear factor 1) and a repressive transcription factor, ATBF1 (AT motif binding factor 1). CAT assays showed the direct inhibition of AFP gene expression by ATBF1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254447 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 9792724 |
AFP promoter-chloramphenicol acetyltransferase transient transfection assays demonstrated that the level of HNF1 had a direct impact on basal transcription as well as RA-mediated down-regulation of the AFP gene, and that co-transfection of HNF1 and HNF4, but not transfection of either factor alone, reversed the RA-mediated inhibition. Taken together these data point to an interaction among the RA, HNF1, and HNF4 signals, which is reflected in decreased expression of AFP. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10050749 |
Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1α |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
AKR1C4 |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2044952 |
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-1_ binds to the target element in the rat DBP gene in the liver, while vHNF-1 recognizes a target element in extrahepatic tissues. The ability of vHNF-1-A to activate the rat DBP gene is much higher than that of vHNF-1-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | down-regulates quantity by repression 
transcriptional regulation
|
ABCB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282663 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 31103629 |
The transcriptional activation of ABCB1 in PANC-1 cells was inhibited in stably HNF1A overexpressed cells and enhanced in HNF1A depleted cells. the mRNA and protein levels of ABCB1 and ABCC1 were significantly decreased in PANC-1 and MIA PaCa-2 cell lines after overexpression of HNF1A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270224 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLC22A9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268982 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 20829431 |
Luciferase reporter gene constructs containing the OAT5 (SLC22A10) and OAT7 (SLC22A9) promoter regions were transactivated by HNF-1 in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
CDH17 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253970 |
|
|
Homo sapiens |
HEP-3B Cell, MHCC-97 Cell |
| pmid |
sentence |
| 20568120 |
The present study aims to identify the transcription factors which interact and regulate CDH17 promoter activity that might contribute to the up-regulation of CDH17 gene in human HCC|we identified hepatic nuclear factor 1α (HNF1α) and caudal-related homeobox 2 (CDX2) binding sites at the proximal promoter region which modulate the CDH17 promoter activities in two HCC cell lines (Hep3B and MHCC97L) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268988 |
|
|
|
|
| pmid |
sentence |
| 16741617 |
Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.|This study demonstrated that the transcription of the LST-2 gene is regulated by three transcription factors, FXR, HNF1alpha, and HNF3beta. |
|
| Publications: |
1 |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
FGFR4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282662 |
|
|
Homo sapiens |
Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 40731412 |
HNF1A drives PDAC liver metastasis in vivo. we identified HNF1A as a key driver of metastasis via transcriptional regulation of its target gene FGFR4. . In the current study, we identify HNF1A as an oncogenic transcription factor that drives metastasis in PDAC, and it does so through upregulation of the receptor tyrosine kinase FGFR4. HNF1A directly binds to the FGFR4 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | down-regulates quantity by repression
transcriptional regulation
|
ABCC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282664 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 31103629 |
The transcriptional activation of ABCB1 in PANC-1 cells was inhibited in stably HNF1A overexpressed cells and enhanced in HNF1A depleted cells. the mRNA and protein levels of ABCB1 and ABCC1 were significantly decreased in PANC-1 and MIA PaCa-2 cell lines after overexpression of HNF1A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gemcitabine | down-regulates quantity by repression
|
HNF1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282665 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 31103629 |
We found a decreased expression of HNF1A at the mRNA and protein levels after gemcitabine treatment at 1 μM and 10 μM concentrations for 12 h. Immunofluorescence further demonstrated an inhibition of HNF1A expression in the nucleus after gemcitabine treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A8 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253972 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254437 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18172616 |
This study indicates that hepatocyte nuclear factor 1alpha (HNF1alpha) bound to the proximal promoter motif not only enhances the basal reporter activity of UGT1A1, including the distal (-3570/-3180) and proximal (-165/-1) regions, but also influences the transcriptional regulation of UGT1A1 by CAR, PXR, GR, and AhR to markedly enhance reporter activities. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLC22A10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268983 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 20829431 |
Luciferase reporter gene constructs containing the OAT5 (SLC22A10) and OAT7 (SLC22A9) promoter regions were transactivated by HNF-1 in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A10 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253971 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXC11 | up-regulates
|
HNF1A |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-57484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9582375 |
The observed stimulatory effect of hoxc11 on hnf1_ may be due to a similar stabilizing effect on hnf1_ dna binding and/or an increase in transcriptional activity of hnf1_. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A9 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253973 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
HNF1A
- 
- 