| Name | FLNA |
| ID | P21333 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 1 43-149 PROSITE-ProRule
Calponin-homology (CH) 2 166-269 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | FLNA | Ser2152 | TRRRRAPsVANVGSH | phosphorylation up-regulates | 12198493 | SIGNOR-92065 |
| PPP3CB | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates quantity by destabilization | 16442073 | SIGNOR-248362 |
| RPS6KA1 | FLNA | Ser2152 | TRRRRAPsVANVGSH | phosphorylation up-regulates | 15024089 | SIGNOR-123458 |
| PPP3CC | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates quantity by destabilization | 16442073 | SIGNOR-248507 |
| STK38L | FLNA | Ser2152 | TRRRRAPsVANVGSH | phosphorylation up-regulates activity | 30568657 | SIGNOR-278501 |
| PRKACA | FLNA | Ser2152 | TRRRRAPsVANVGSH | phosphorylation up-regulates | 15228085 | SIGNOR-126659 |
| PPP3CA | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates | 16442073 | SIGNOR-143979 |
| CAMK2G | FLNA | Ser2523 | VTGPRLVsNHSLHET | phosphorylation unknown | 11290523 | SIGNOR-250696 |
| Calcineurin | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates | 16442073 | SIGNOR-252339 |
| RPS6K | FLNA | Ser2152 | TRRRRAPsVANVGSH | phosphorylation up-regulates | 15024089 | SIGNOR-252790 |
| PP2B | FLNA | – | dephosphorylation down-regulates quantity by destabilization | 16442073 | SIGNOR-269986 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | phosphorylation up-regulates → | FLNA PSer2152 | phosphorylation up-regulates → | FLNA | 12198493 | SIGNOR-92065 |
| PPP3CB | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-248362 |
| RPS6KA1 | phosphorylation up-regulates → | FLNA PSer2152 | phosphorylation up-regulates → | FLNA | 15024089 | SIGNOR-123458 |
| PPP3CC | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-248507 |
| STK38L | phosphorylation up-regulates → | FLNA PSer2152 | phosphorylation up-regulates → | FLNA | 30568657 | SIGNOR-278501 |
| PRKACA | phosphorylation up-regulates → | FLNA PSer2152 | phosphorylation up-regulates → | FLNA | 15228085 | SIGNOR-126659 |
| PPP3CA | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-143979 |
| CAMK2G | phosphorylation up-regulates → | FLNA PSer2523 | phosphorylation down-regulates ⊣ | FLNA | 11290523 | SIGNOR-250696 |
| Calcineurin | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-252339 |
| RPS6K | phosphorylation up-regulates → | FLNA PSer2152 | phosphorylation up-regulates → | FLNA | 15024089 | SIGNOR-252790 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK1 | phosphorylation → up-regulates | FLNA | SIGNOR-92065 |
| PPP3CB | dephosphorylation down-regulates quantity by destabilization | FLNA | SIGNOR-248362 |
| RPS6KA1 | phosphorylation → up-regulates | FLNA | SIGNOR-123458 |
| PPP3CC | dephosphorylation down-regulates quantity by destabilization | FLNA | SIGNOR-248507 |
| STK38L | phosphorylation → up-regulates activity | FLNA | SIGNOR-278501 |
| PRKACA | phosphorylation → up-regulates | FLNA | SIGNOR-126659 |
| PPP3CA | dephosphorylation down-regulates | FLNA | SIGNOR-143979 |
| CAMK2G | phosphorylation → unknown | FLNA | SIGNOR-250696 |
| Calcineurin | dephosphorylation down-regulates | FLNA | SIGNOR-252339 |
| RPS6K | phosphorylation → up-regulates | FLNA | SIGNOR-252790 |
| PP2B | dephosphorylation down-regulates quantity by destabilization | FLNA | SIGNOR-269986 |